Concept

Anterograde tracing

Publications associées (28)

Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing

Carl Petersen, Sylvain Crochet, Yves Emile Alfred Kremer

Internal brain states affect sensory perception, cognition, and learning. Many neocortical areas exhibit changes in the pattern and synchrony of neuronal activity during quiet versus active behaviors. Active behaviors are typically associated with desynchr ...

Elsevier2014

Mesenchymal stem cells restore cortical rewiring after neonatal ischemia in mice

Yohan Van de Looij

Objective: A study was undertaken to investigate the effect of neonatal hypoxic-ischemic (HI) brain damage and mesenchymal stem cell (MSC) treatment on the structure and contralesional connectivity of motor function-related cerebral areas. Methods: Brain r ...

Wiley-Blackwell2012

High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice

Rolf Gruetter, Hongxia Lei, Malte Alf

After ischemic stroke, the ischemic damage to brain tissue evolves over time and with an uneven spatial distribution. Early irreversible changes occur in the ischemic core, whereas, in the penumbra, which receives more collateral blood flow, the damage is ...

Wiley-Blackwell2012

Neuroprotection by Gene Therapy Targeting Mutant SOD1 in Individual Pools of Motor Neurons Does not Translate Into Therapeutic Benefit in fALS Mice

Patrick Aebischer, Bernard Schneider, Christopher Towne, Veronica Setola

A major challenge in neurological gene therapy is delivery of the transgene to sufficient cell numbers in an atraumatic manner. This is particularly difficult for motor neuron (MN) diseases that have cells located across the entire spinal cord, brain stem, ...

Elsevier2010

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

Steinunn Baekkeskov Hanahan

T he inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. Whereas GAD67 is constitutively active and produces >90% of GABA in the central nervous system ...

Rockefeller University Press2010

White matter maturation reshapes structural connectivity in the late developing human brain

Jean-Philippe Thiran, Patric Hagmann, Reto Meuli, Leila Cammoun, Leila Faiza Ben Hamida Cammoun

From toddler to late teenager, the macroscopic pattern of axonal projections in the human brain remains largely unchanged while undergoing dramatic functional modifications that lead to network refinement. These functional modifications are mediated by inc ...

National Academy of Sciences2010

Global brain connectivity analysis by diffusion MR tractography : algorithms, validation and applications

Xavier Gigandet

The human cerebral cortex consists of approximately 1010 neurons that are organized into a complex network of local circuits and long-range connections. During the past years there has been an increasing interest from the neuro-scientific community towards ...

EPFL2009

The Structural Core of Human Cerebral Cortex and its relation to the brain s default network

Reto Meuli, Leila Cammoun, Xavier Gigandet, Leila Faiza Ben Hamida Cammoun

Human cerebral cortex contains an uncertain number of structurally segregated regions interconnected by a dense network of axonal pathways. Using DSI, we map these pathways in individual human subjects. An analysis of the resulting large-scale structural b ...

2008