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In physics, engineering and materials science, bi-isotropic materials have the special optical property that they can rotate the polarization of light in either refraction or transmission. This does not mean all materials with twist effect fall in the bi-isotropic class. The twist effect of the class of bi-isotropic materials is caused by the chirality and non-reciprocity of the structure of the media, in which the electric and magnetic field of an electromagnetic wave (or simply, light) interact in an unusual way. For most materials, the electric field E and electric displacement field D (as well as the magnetic field B and inductive magnetic field H) are parallel to one another. These simple mediums are called isotropic, and the relationships between the fields can be expressed using constants. For more complex materials, such as crystals and many metamaterials, these fields are not necessarily parallel. When one set of the fields are parallel, and one set are not, the material is called anisotropic. Crystals typically have D fields which are not aligned with the E fields, while the B and H fields remain related by a constant. Materials where either pair of fields is not parallel are called anisotropic. In bi-isotropic media, the electric and magnetic fields are coupled. The constitutive relations are D, E, B, H, ε and μ are corresponding to usual electromagnetic qualities. ξ and ζ are the coupling constants, which is the intrinsic constant of each media. This can be generalized to the case where ε, μ, ξ and ζ are tensors (i.e. they depend on the direction within the material), in which case the media is referred to as bi-anisotropic. ξ and ζ can be further related to the Tellegen (referred to as reciprocity) χ and chirality κ parameter after substitution of the above equations into the constitutive relations, gives Pasteur media can be made by mixing metal helices of one handedness into a resin. Care must be exercised to secure isotropy: the helices must be randomly oriented so that there is no special direction.