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Concept

Neuroendocrine cell

Publications associées (23)

Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development

Jörg Hülsken, Anne Grapin-Botton

Mutations and deregulation of adenomatous polyposis coli (APC) and beta-catenin are implicated in specific cancers of the pancreas, but the role of Wnt pathway in normal pancreas development and homeostasis is unknown [1-4]. This article reports a comprehe ...

2005

Ductal cells of the pancreas

Anne Grapin-Botton

Ductal cells of the pancreas form the epithelial lining of the branched tubes that deliver enzymes produced by pancreatic acinar cells into the duodenum. In addition, these cells secrete bicarbonate that neutralizes stomach acidity. During development, epi ...

2005

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes

Anne Grapin-Botton

The mechanisms by which the epithelium of the digestive tract and its associated glands are specified are largely unknown. One clue is that several transcription factors are expressed in specific regions of the endoderm prior to and during organogenesis. P ...

2001