Publications associées à Mutisme sélectif

Robot-induced hallucinations in Parkinson’s disease depend on altered sensorimotor processing in fronto-temporal network

Dimitri Nestor Alice Van De Ville, Olaf Blanke, Nathan Quentin Faivre, Giulio Rognini, Fosco Bernasconi, Michela Bassolino, Jevita Potheegadoo, Michel Akselrod, Eva Blondiaux, Giedre Stripeikyte, Matteo Franza

Hallucinations in Parkinson’s disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the inducti ...

2021

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Oliver Hantschel, Florence Pojer, Kelvin Ka Ching Lau, Tim Kükenshöner, Grégory La Sala

The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere ...

Nature Research2020

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Oliver Hantschel, Florence Pojer, Tim Kükenshöner, Nadine Eliane Schmit

The binding of Src-homology 2 (SH2) domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the eight Src family kinases (SFKs). The high sequence conservation of the 120 human SH2 domains poses a significant c ...

Elsevier2017

Shape-Selective Assembly of Anisotropic, Deformable Microcomponents Using Bottom-Up Micromanufacturing

Gunjan Agarwal

A technique for shape-selective directed assembly of anisotropic, deformable, chemically-identical microcomponents onto patterned rigid templates based on shape and size differences is modeled and demonstrated. The assembly method not only controls the sel ...

Mdpi Ag2016

Social deficits induced by peripubertal stress in rats are reversed by resveratrol

Maria del Carmen Sandi Perez, Olivia Zanoletti, Guillaume Poirier

Adolescence is increasingly recognized as a critical period for the development of the social system, through the maturation of social competences and of their underlying neural circuitries. The present study sought to test the utility of resveratrol, a di ...

2014

"Self pop-out": agency enhances self-recognition in visual search

Olaf Blanke, Roy Salomon, Oliver Alan Kannape, Joan Llobera Mahy

In real-life situations, we are often required to recognize our own movements among movements originating from other people. In social situations, these movements are often correlated (for example, when dancing or walking with others) adding considerable d ...

Springer2013

Tuning the Chemoselectivity of Rh Nanoparticle Catalysts by Site-Selective Poisoning with Phosphine Ligands: The Hydrogenation of Functionalized Aromatic Compounds

Paul Joseph Dyson, Gabor Laurenczy, Ning Yan, Weijia Gan, Dennis Snelders

The hydrogenation of phenylacetone to cyclohexylacetone, in which the aromatic ring is selectively reduced in preference to the carbonyl group, has been achieved with chemoselectivities exceeding 90%. The catalyst (precatalyst) used to achieve this transfo ...

2012

Novel organometallic ruthenium complexes for selective activation in tumour cells

Anna Katherine Renfrew

In recent years, ruthenium-based antitumour drugs have emerged as an attractive alternative to cisplatin, exhibiting both excellent activity in tumours where cisplatin is of limited use and low general toxicity, leading to reduced side effects. Two rutheni ...

EPFL2010

The role of the amygdala in emotional memories : a multidisciplinary approach

Maria del Carmen Sandi Perez, Kamila Markram

This thesis investigates the role of the amygdala for the establishment of fear memories with a multidisciplinary approach, including behavioural, psychopharmacological, genetic, molecular, and electrophysiological techniques in rats or mice, under healthy ...

EPFL2007