Concept

Organisation

Publications associées (25)

Inheritance of H3K9 methylation regulates genome architecture in Drosophila early embryos

Constitutive heterochromatin is essential for transcriptional silencing and genome integrity. The establishment of constitutive heterochromatin in early embryos and its role in early fruitfly development are unknown. Lysine 9 trimethylation of histone H3 ( ...

Springernature2024

Assessing the readiness of municipalities for digital process innovation

Mert Duygan

Pre-adoption phases of innovation are understudied in the innovation literature. This article addresses preadoption phases of innovation by running a prospective analysis. We assess the readiness of municipalities for the adoption of a digital tool that br ...

ELSEVIER SCI LTD2023

A conceptual construct on value for infrastructure asset management

Matthias Finger

Understanding the meaning of value to asset-intensive organizations and their stakeholders has been a long -standing goal of researchers and managers of the asset management community. These issues have become particularly prominent with the publication of ...

ELSEVIER SCI LTD2022

The neocortical column as a universal template for perception and world-model learning

Mackenzie Mathis

Mackenzie Mathis highlights an essay by Vernon Mountcastle that shaped our understanding of the organization and function of the neocortex. ...

NATURE PORTFOLIO2022

A Theory of Value for Service Ecosystems

Blagovesta Hristova Kostova

In this thesis, we present a theory of value for the design and analysis of service ecosystems. The theory is based on general systems thinking. The concept of a system is used for relating knowledge from different disciplines (such as software engineering ...

EPFL2022

Designing Horizontality

Paola Viganò, Tommaso Pietropolli

This paper is divided into three parts. The first introduces a trilogy of concepts and figures of the discourse. The concept of isotropy, as opposed to hierarchy, evokes the same conditions in all directions. The concept of porosity tackles the fluidity an ...

ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD2021

Risk governance and the rise of deepfakes

Touradj Ebrahimi, Aengus Killian Collins

Deepfakes first came to prominence less than five years ago. Since then, they have surged in quantity and quality, becoming both a source of viral entertainment and of concern about the dark side of digital life. In this article, we provide a risk governan ...

International Risk Governance Center2021

Structural architecture of the Neuronal-Glial-Vascular system

Eleftherios Zisis

Brain functionality relies on the neuronal-glial-vascular (NGV) ensemble for energy support. However, the details of the complex biological mechanisms involved in these processes and the microscopic interactions between these three components are not yet f ...

EPFL2021

Entrepreneurship across Sociocultural Contexts: Empirical and Theoretical Perspectives

Shirah Eden Foy

Entrepreneurship is a highly contextualized process. Yet, the vast majority of entrepreneurship research has focused on Western contexts, yielding a skewed picture of global entrepreneurial behavior. Moreover, theories of mainstream psychology explaining t ...

EPFL2020

Palimpsest Metaphor: Figures and Spaces of the Contemporary Project

Paola Viganò

What are the consequences of the use of the palimpsest metaphor on the construction of the contemporary project? The metaphor casts criticism on the modern project and opens to the long-term (longue durée). The investigation of territorial rationalities br ...

2020

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

Hilal Lashuel, Graham Knott, Johannes Burtscher, Marion Leleu, Fabien Kuttler, Mary-Claude Croisier-Coeytaux, Anne-Laure Mahul Mellier, Niran Maharjan, Laura Emmeline H Weerens

Parkinson’s disease (PD) is characterized by the accumulation of misfolded and aggregated α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is widely believed that α-syn plays a central role in the pathogenesis of PD, t ...

National Academy of Sciences2020

Creating New Ventures: A Review and Research Agenda

Marc Gruber

Creating new ventures is one of the most central topics to entrepreneurship and is a critical step from which many theories of management, organizational behavior, and strategic management build. Therefore, this review and proposed research agenda are rele ...

SAGE PUBLICATIONS INC2020

Development of chemical biology tools to reveal the function and organization of the silenced chromatin state

Nora Guidotti

Effector proteins are recruited to chromatin via transient interactions between their reader domains and histone post-translational modification (PTM) patterns. These interactions form signaling pathways that control gene expression or repression and which ...

EPFL2020

The organisation of science: topics, incentives and funding

Omar Ballester Gonzalez

Ever since the links between the development of new technologies and economic growth became evident, researchers have attempted to study how the creation of knowledge fosters progress. If pushing the frontier of knowledge has an impact on progress and well ...

EPFL2020

Gamifying knowledge sharing in humanitarian organisations: a design science journey

Denis Gillet, Adrian Christian Holzer, Isabelle Barbara Marie-Hélène Cardia, Samuel Bendahan

Humanitarian organisations provide invaluable work to improve the lives of individuals impacted by natural and anthropogenic hazards. While humanitarian organisations are highly knowledge intensive, they often fail to manage knowledge effectively. Providin ...

2020

cGAS regulation and activity during genotoxic stress

Sélène-Véronique Glück

The innate immune system has evolved to detect pathogens through germlineencoded pattern recognition receptors (PRRs). Nucleic acid sensors, a defined class of PRRs, bind to microbial and viral nucleic acids and trigger the production of type I interferons ...

EPFL2020

Testing Analytical Frameworks in Transdisciplinary Research for Sustainable Development

Jean-Claude Bolay, Gabriela Tejada Guerrero, Silvia Hostettler, Clémence Noëlie Marie Ranquet Bouleau, Marina Cracco

This article discusses the concept and the practice of transdisciplinary research, including how it is conceived and implemented through the cooperation of different actors involved. With transdisciplinarity gaining recognition as an approach to addressing ...

2019

Meeting Report – The 2019 FEBS special meeting on sphingolipid biology: sphingolipids in physiology and pathology

Giovanni D'Angelo

Sphingolipids are a fundamental class of molecules that are involved in structural, organizational and signaling properties of eukaryotic membranes. Defects in their production or disposal lead to acquired and inherited human diseases. A growing community ...

2019

Visualizing sphingolipid biosynthesis in cells

Biosynthetic pathways play a fundamental role in the building and operation of the cell by synthesizing the constituents by which the cell is constructed, and by producing signalling intermediates that play a key role in cell regulation. While a lot is kno ...

2019

Cidade e interação: o papel do espaço urbano na organização social [City and interaction: the role of space in social organization]

João Vitor Meirelles de Miranda

Como ações pessoais, aparentemente caóticas, podem gerar os imensos sistemas de interações em que vivemos? Neste artigo, buscamos responder a esta pergunta sugerindo que há um papel para as cidades, na forma de coordenar nossas ações. Investigamos esse pro ...

PONTIFICIA UNIV CATOLICA PARANA-PUCPR2018