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Publications associées (37)

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The conceptual foundations of innate immunity: Taking stock 30 years later

Bruno Lemaitre

While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, ...

2024

A fatty-acid based probe for near-infrared fluorescence guided surgery of glioblastoma

Elena Goun, Pavlo Khodakivskyi

High-grade gliomas (HGG) are the most common and most aggressive primary tumors of the brain. Despite recent advances in neuro-oncology survival of these tumors remains around 12-15 months. The first-line of treatment is surgical resection. However, due to ...

Spie-Int Soc Optical Engineering2024

Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

Natasha Ella Samson

Inflammation stands as a dynamic and intricate biological process, promoting vital defence mechanisms against harmful stimuli, including infections and injuries, to drive pathogen clearance and healing. On one hand, these responses can manifest acutely and ...

EPFL2024

Deconvolution of ex-vivo drug screening data and bulk tissue expression predicts the abundance and viability of cancer cell subpopulations

Alexandre Coudray

Ex-vivo drug sensitivity screening (DSS) allows the prediction of cancer treatment effectiveness in a personalized fashion. However, it only provides a readout on mixtures of cells, potentially occulting important information on clinically relevant cell su ...

EPFL2023

Multimodal fusion of liquid biopsy and CT enhances differential diagnosis of early-stage lung adenocarcinoma

Li Zhang, Jiancheng Yang

This research explores the potential of multimodal fusion for the differential diagnosis of early-stage lung adenocarcinoma (LUAD) (tumor sizes < 2 cm). It combines liquid biopsy biomarkers, specifically extracellular vesicle long RNA (evlRNA) and the comp ...

Nature Portfolio2024

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

Beat Fierz, Pauline Franz

Since Strahl and Allis proposed the "language of covalent histone modifications", a host of experimental studies have shed light on the different facets of chromatin regulation by epigenetic mechanisms. Initially proposed as a concept for controlling gene ...

Academic Press Ltd- Elsevier Science Ltd2024

Mini-colons unlock tumour development outside the body

Luis Francisco Lorenzo Martin, Matthias Lütolf

In this Tools of the Trade article, Francisco Lorenzo-Mart & iacute;n and Matthias Lutolf present mini-colons as a new ex vivo cancer model that incorporates microfabrication, tissue engineering and optogenetics. ...

Nature Portfolio2024

Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

Henning Paul-Julius Stahlberg, Dongchun Ni

ABCG2 is an ATP-binding cassette transporter that exports a wide range of xenobiotic compounds and has been recognized as a contributing factor for multidrug resistance in cancer cells. Substrate and inhibitor interactions with ABCG2 have been extensively ...

Academic Press Ltd- Elsevier Science Ltd2023

Competitive binding studies of the nucleosomal histone targeting drug, [Ru (eta(6)-p-cymene)Cl-2(pta)] (RAPTA-C), with oligonucleotide-peptide mixtures

Paul Joseph Dyson, Daniel Ortiz Trujillo

Protein crystallography and biochemical assays reveal that the organometallic drug, [Ru(eta(6)-p-cymene)Cl-2(pta)] (RAPTA-C), preferentially binds to nucleosomal histone proteins in chromatin. To better understand the binding mechanism we report here a mas ...

ELSEVIER SCIENCE INC2023

DNA-based biomaterials for nanoscale controlled modulation of immune cells

Alice Comberlato

Recent advances in the field of nanomaterials demonstrated how their use for vaccination can drastically improve immune responses, mainly by enhancing delivery and uptake of vaccine components. However, our understanding of the connections between presenta ...

EPFL2022

Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis

Bruno Lemaitre, Jean Philippe Boquete, Zongzhao Zhai

Stem cell self-renewal and differentiation are coordinated to maintain tissue homeostasis and prevent cancer. Mutations causing stem cell proliferation are traditionally the focus of cancer studies. However, the contribution of the differentiating stem cel ...

Nature Publishing Group2015

Automatic evaluation of cyclooxygenase 2 inhibition induced by metal-based anticancer compounds

Paul Joseph Dyson

An automatic methodology based on micro sequential injection analysis coupled to a lab-on-valve system (termed ?SIA-LOV) was developed and used to determine the ability of metal-based anticancer compounds to inhibit cyclooxygenase 2 (COX-2) activity. COX-2 ...

ELSEVIER SCIENCE INC2021

Scleractinian coral morphogenesis : searching for stem cells and precursors of the skeletogenic calicodermis

Agathe Eliette Marie Lecointe

Metamorphosis is a crucial step in the life cycle of a scleractinian coral: The swimming coral larva, the planula, settles, and metamorphoses into a sessile calcifying primary polyp, which subsequently grows into an adult colony. Importantly, morphogenesis ...

EPFL2016

Preparation and medical use of triazenes

Kay Severin, Gregor Kiefer

The present invention relates to a novel method for preparing triazenes. Further, the invention relates to novel triazenes and the use of N2O for preparing a compound comprising a triazene group. Further, the invention relates to the use of the novel triaz ...

2015

In vitro Ruthenation of Human Breast Cancer Suppressor Gene 1 (BRCA1) by the Antimetastasis Compound RAPTA-C and Its Analogue CarboRAPTA-C

Paul Joseph Dyson

The interaction of two ruthenium-arene-1,3,5-triaza-7-phosphaadamantane compds. ([Ru(η6-p-cymene)Cl2(pta)] and [Ru(η6-p-cymene)(C6H6O4)(pta)], termed RAPTA-C (3) and carboRAPTA-C (4), resp.) with the DNA sequence of the human breast-cancer suppressor gene ...

Wiley-Blackwell2010

5-Fluorouracil Release from Chitosan-Based Matrix. Experimental and Theoretical Aspects

Maria-Alexandra Paun

A series of four drug release formulations based on 5-fluorouracil encapsulated into a chitosan-based matrix were prepared by in situ hydrogelation with 3,7-dimethyl-2,6-octadienal. The formulations were investigated from structural and morphological aspec ...

2020

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Graham Knott, Douglas Hanahan, Brian Donal McCabe, Iacovos Michael, Mohammad Sadegh Saghafinia, Wei Jiao, Qiqun Zeng

Metastasis-the disseminated growth of tumours in distant organs-underlies cancer mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and is prevalent in the aggressive basal-like subtype, but is also found at varying freq ...

2019