Publications related to Lymphatica

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Implanted medical devices (IMDs) have been widely developed to support the monitoring and recording of biological data inside the body or brain. Wirelessly powered IMDs, a subset of implantable electronics, have been proposed to eliminate the limitations r ...

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

The integration of technology in the medical field has greatly improved accuracy in diagnoses, thus leading to more effective treatments. Wearable and implantable medical devices offer great potential for remote patient monitoring, particularly for heart f ...

Over the last 20 years, the field of Smart Dust has been proposed and demonstrated. Almost in the same period, implantable and wearable sensors for human monitoring have been actually successfully introduced in the market. The present research about Smart ...

The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc ...

Neural interfaces are devices that are implanted into the body and interface electrically with the central (CNS) or peripheral nervous system. They are inserted surgically for short periods of time or chronically to diagnose or treat several neural disease ...

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

Understanding the interactions between biomedical alloys and body fluids is of importance for the successful and safe performance of implanted devices. Albumin, as the first protein that comes in contact with an implant surface, can determine the biocompat ...

Objective: Despite recent advances in pharmacological research and microsurgery, lymphoedema remains an incurable disease that deeply affects quality of life. There is an urgent need for innovative approaches to restore continuous lymph flow in affected ti ...

Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors ...

Liquid biopsies allow monitoring of cancer progression and detection of relapse, but reliable biomarkers in melanoma are lacking. Because secreted factors preferentially drain to lymphatic vessels before dilution in the blood, we hypothesized that lymph sh ...

The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materia ...

Spinal cord injury (SCI) disrupts communication within central nervous system and lead to range of neurological disorders including paralysis. Current rehabilitation strategies to restore locomotion are poorly effective in people with severe SCI. Epidural ...

The mammalian lymphatic system consists of strategically located lymph nodes (LNs) embedded into a lymphatic vascular network. Mechanisms underlying development of this highly organized system are not fully understood. Using highresolution imaging, we show ...

Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic vessel density (LVD) ...

Knee implant loosening is mainly caused by the weakness of the prosthesis-bone interface and is the main reason for surgical revisions. However, pre-operative diagnosis is difficult due to lack of accurate tests. In this study, we developed a vibration-bas ...

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour ...

A power and area effcient hardware encoding system tailored for wireless implantable applications is presented. Constant medical monitoring allowed by implantable devices is the most relevant alternative to current bulky monitoring systems, which, in case ...

A power and area efficient hardware encoding system tailored for wireless implantable applications is presented. Constant medical monitoring allowed by implantable devices is the most relevant alternative to current bulky monitoring systems, which, in case ...

Rationale: The transport of interstitial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering antigens and soluble factors to the lymph node for immune surveillance. Transendothelial transport across ...

Lymphatica

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Integrated Wireless Power, Data Communication, and Thermal Sensing System for Autonomous Multisite Brain Implants

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Integrated Electronics for Deep Implants to Remotely Monitor Hemodynamics

Body Dust: Well Beyond Wearable and Implantable Sensors

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Integration of hybrid material systems in conformable neural interfaces

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

An Overview of Serum Albumin Interactions with Biomedical Alloys

Experimental Drainage Device to Reduce Lymphoedema in a Rat Model

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

Rapid evaluation of bioactive Ti-based surfaces using an in vitro titration method

Spatiotemporal stimulation strategies in neuroprostheses to improve locomotion after spinal cord injury

Multiple roles of lymphatic vessels in peripheral lymph node development

Lymphatic vessel density is associated with CD8(+) T cell infiltration and immunosuppressive factors in human melanoma

Knee Implant Loosening Detection: A Vibration Analysis Investigation

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

An area and power efficient on-the-fly LBCS transformation for implantable neuronal signal acquisition systems

An area and power efficient on-the-fly LBCS transformation for implantable neuronal signal acquisition systems

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress