Plasma biomarkers for Alzheimer's disease: a field-test in a memory clinic

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PET-based prognostic survival model after radiotherapy for head and neck cancer

Adrien Raphaël Depeursinge, Xiaolu Sun

PurposeThe aims of this multicentre retrospective study of locally advanced head and neck cancer (LAHNC) treated with definitive radiotherapy were to (1) identify positron emission tomography (PET)-F-18-fluorodeoxyglucose (F-18-FDG) parameters correlated w ...

SPRINGER2019

Bioluminescent-based imaging and quantification of glucose uptake in vivo

Elena Goun, Riccardo Sinisi, Arkadiy Bazhin, Pavlo Khodakivskyi, Tamara Maric, Aleksey Yevtodiyenko, Georgy Mikhaylov

Glucose is a major source of energy for most living organisms, and its aberrant uptake is linked to many pathological conditions. However, our understanding of disease-associated glucose flux is limited owing to the lack of robust tools. To date, positron- ...

NATURE PUBLISHING GROUP2019

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti

Background: Effects of beta-amyloid accumulation on neuronal function precede the clinical manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain networks. As previous studies suggest a link between beta-amyloid and dysregul ...

2019

Microwave Imaging of Brain Stroke : Contributions to Modeling and Inverse Problem Resolution

Mina Bjelogrlic

Brain stroke is an age-related illness which has become a major issue in our ageing societies. Early diagnosis and treatment are of high importance for the full recovery of the patient, as reminded in Anglo-Saxon countries by the abbreviation FAST (Face, A ...

EPFL2018

In vivo (13)C MRS in the mouse brain at 14.1 Tesla and metabolic flux quantification under infusion of [1,6-(13)C2]glucose

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Carole Poitry-Yamate, Marta Lai

In vivo (13)C magnetic resonance spectroscopy (MRS) enables the investigation of cerebral metabolic compartmentation while, e.g. infusing (13)C-labeled glucose. Metabolic flux analysis of (13)C turnover previously yielded quantitative information of glutam ...

2018

IoT for Telemedicine Practices enabled by an Android (TM) Application with Cloud System Integration

Sandro Carrara, Danilo Demarchi, Francesca Stradolini, Abuduwaili Tuoheti

Connected medical devices are already paving the way towards the realization of Smart Hospitals where patient care is improved thanks to Internet of Things (IoT) solutions. Following this trend, in this paper we propose an IoT cloud-based network for anest ...

IEEE2018

Privacy - Preserving Data Exchange and Aggregation in Healthcare

Alevtina Dubovitskaya

Medical data are often scattered among multiple clinics, hospitals, insurance companies, pharmacies, and research institutions that store and process personal healthcare information. The use of information and communication technologies for health (eHealth ...

EPFL2018

Nanoparticle-Enhanced Plasmonic Biosensor for Digital Biomarker Detection in a Microarray

Hatice Altug, Filiz Yesilköy, Alexander Belushkin

Nanoplasmonic devices have become a paradigm for biomolecular detection enabled by enhanced light–matter interactions in the fields from biological and pharmaceutical research to medical diagnostics and global health. In this work, we present a bright-fiel ...

2018

In vivo cerebral metabolism of glioblastoma xenografts assessed with ¹H MRS, ¹³C MRS and ¹⁸F-FDG PET

Marta Lai

Magnetic resonance spectroscopy (MRS) is a powerful tool when studying metabolism in intact and living organs preserving cells in their natural microenvironment with minimal external interference. The unique insights offered by the observation of metabolic ...

EPFL2017

Real-time classification technique for early detection and prevention of myocardial infarction on wearable devices

David Atienza Alonso, Amir Aminifar, Dionisije Sopic

Continuous monitoring of patients suffering from cardiovascular diseases and, in particular, myocardial infarction (MI) places a considerable burden on health-care systems and government budgets. The rise of wearable devices alleviates this burden, allowin ...

IEEE2017