Drug designDrug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it.
Drug discoveryIn the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology.
Biological targetA biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function. Examples of common classes of biological targets are proteins and nucleic acids. The definition is contcan refer to the biological target of a pharmacologically active drug compound, the receptor target of a hormone (like insulin), or some other target of an external stimulus.
Instruction pipeliningIn computer engineering, instruction pipelining is a technique for implementing instruction-level parallelism within a single processor. Pipelining attempts to keep every part of the processor busy with some instruction by dividing incoming instructions into a series of sequential steps (the eponymous "pipeline") performed by different processor units with different parts of instructions processed in parallel. In a pipelined computer, instructions flow through the central processing unit (CPU) in stages.
SurgerySurgery is a medical specialty that uses manual and/or instrumental techniques to physically reach into a subject's body in order to investigate or treat pathological conditions such as a disease or injury, to alter bodily functions (e.g. bariatric surgery such as gastric bypass), to improve appearance (cosmetic surgery), or to remove/replace unwanted tissues (body fat, glands, scars or skin tags) or foreign bodies. The subject receiving the surgery is typically a person (i.e. a patient), but can also be a non-human animal (i.
BiosignatureA biosignature (sometimes called chemical fossil or molecular fossil) is any substance – such as an element, isotope, or molecule – or phenomenon that provides scientific evidence of past or present life. Measurable attributes of life include its complex physical or chemical structures and its use of free energy and the production of biomass and wastes. A biosignature can provide evidence for living organisms outside the Earth and can be directly or indirectly detected by searching for their unique byproducts.
Pipeline (computing)In computing, a pipeline, also known as a data pipeline, is a set of data processing elements connected in series, where the output of one element is the input of the next one. The elements of a pipeline are often executed in parallel or in time-sliced fashion. Some amount of buffer storage is often inserted between elements. Computer-related pipelines include: Instruction pipelines, such as the classic RISC pipeline, which are used in central processing units (CPUs) and other microprocessors to allow overlapping execution of multiple instructions with the same circuitry.
Biological activityIn pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or pharmacophore but can be modified by the other constituents. Among the various properties of chemical compounds, pharmacological/biological activity plays a crucial role since it suggests uses of the compounds in the medical applications.
Magnetic resonance imagingMagnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from computed tomography (CT) and positron emission tomography (PET) scans.
Tissue (biology)In biology, tissue is a historically derived biological organizational level between cells and a complete organ. A tissue is therefore often thought of as an assembly of similar cells and their extracellular matrix from the same origin that together carry out a specific function. Organs are then formed by the functional grouping together of multiple tissues. The English word "tissue" derives from the French word "tissu", the past participle of the verb tisser, "to weave".
Pipeline (software)In software engineering, a pipeline consists of a chain of processing elements (processes, threads, coroutines, functions, etc.), arranged so that the output of each element is the input of the next; the name is by analogy to a physical pipeline. Usually some amount of buffering is provided between consecutive elements. The information that flows in these pipelines is often a stream of records, bytes, or bits, and the elements of a pipeline may be called filters; this is also called the pipe(s) and filters design pattern.
Pipeline (Unix)In Unix-like computer operating systems, a pipeline is a mechanism for inter-process communication using message passing. A pipeline is a set of processes chained together by their standard streams, so that the output text of each process (stdout) is passed directly as input (stdin) to the next one. The second process is started as the first process is still executing, and they are executed concurrently. The concept of pipelines was championed by Douglas McIlroy at Unix's ancestral home of Bell Labs, during the development of Unix, shaping its toolbox philosophy.
FluorescenceFluorescence is the emission of light by a substance that has absorbed light or other electromagnetic radiation. It is a form of luminescence. In most cases, the emitted light has a longer wavelength, and therefore a lower photon energy, than the absorbed radiation. A perceptible example of fluorescence occurs when the absorbed radiation is in the ultraviolet region of the electromagnetic spectrum (invisible to the human eye), while the emitted light is in the visible region; this gives the fluorescent substance a distinct color that can only be seen when the substance has been exposed to UV light.
Classic RISC pipelineIn the history of computer hardware, some early reduced instruction set computer central processing units (RISC CPUs) used a very similar architectural solution, now called a classic RISC pipeline. Those CPUs were: MIPS, SPARC, Motorola 88000, and later the notional CPU DLX invented for education. Each of these classic scalar RISC designs fetches and tries to execute one instruction per cycle. The main common concept of each design is a five-stage execution instruction pipeline.
Fluorescence in the life sciencesFluorescence is used in the life sciences generally as a non-destructive way of tracking or analysing biological molecules. Some proteins or small molecules in cells are naturally fluorescent, which is called intrinsic fluorescence or autofluorescence (such as NADH, tryptophan or endogenous chlorophyll, phycoerythrin or green fluorescent protein). Alternatively, specific or general proteins, nucleic acids, lipids or small molecules can be "labelled" with an extrinsic fluorophore, a fluorescent dye which can be a small molecule, protein or quantum dot.
Film frameIn filmmaking, video production, animation, and related fields, a frame is one of the many s which compose the complete moving picture. The term is derived from the historical development of film stock, in which the sequentially recorded single images look like a framed picture when examined individually. The term may also be used more generally as a noun or verb to refer to the edges of the image as seen in a camera viewfinder or projected on a screen. Thus, the camera operator can be said to keep a car in frame by panning with it as it speeds past.
Quantum dotQuantum dots (QDs) – also called semiconductor nanocrystals, are semiconductor particles a few nanometres in size, having optical and electronic properties that differ from those of larger particles as a result of quantum mechanics. They are a central topic in nanotechnology and materials science. When the quantum dots are illuminated by UV light, an electron in the quantum dot can be excited to a state of higher energy. In the case of a semiconducting quantum dot, this process corresponds to the transition of an electron from the valence band to the conductance band.
Frame (networking)A frame is a digital data transmission unit in computer networking and telecommunication. In packet switched systems, a frame is a simple container for a single network packet. In other telecommunications systems, a frame is a repeating structure supporting time-division multiplexing. A frame typically includes frame synchronization features consisting of a sequence of bits or symbols that indicate to the receiver the beginning and end of the payload data within the stream of symbols or bits it receives.
MelanomaMelanoma, also redundantly known as malignant melanoma, is a type of cancer that develops from the pigment-producing cells known as melanocytes. Melanomas typically occur in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). In women, they most commonly occur on the legs, while in men, they most commonly occur on the back. About 25% of melanomas develop from moles. Changes in a mole that can indicate melanoma include an increase in size, irregular edges, change in color, itchiness, or skin breakdown.
Diffusion MRIDiffusion-weighted magnetic resonance imaging (DWI or DW-MRI) is the use of specific MRI sequences as well as software that generates images from the resulting data that uses the diffusion of water molecules to generate contrast in MR images. It allows the mapping of the diffusion process of molecules, mainly water, in biological tissues, in vivo and non-invasively. Molecular diffusion in tissues is not random, but reflects interactions with many obstacles, such as macromolecules, fibers, and membranes.
