Publication

Fluorine as an ally and a spy

Manfred Schlosser
1998
Conference Papers

Abstract

Fluorine, be it as individual atoms or CF3 groups, facilitates and orients the deprotonation of arenes and hetarenes (pyridines etc.). Representative examples will illustrate the concept of "optional site selectivity" in organometallic reactions. Using fluorine as a mechanistic probe, further details of the Wittig reaction sequence have been elucidated. Improved protocols for cis- and trans-selective olefination processes will be disclosed. Organofluorine chemists are often confronted with one central issue:. "What is the effective size of the smallest halogen". A new approach to answer this intriguing question is based on the comparison of organoleptic properties. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/fe61007c-a8d4-4b17-8442-26b088e42f10

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Manfred Schlosser
1998
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/fe61007c-a8d4-4b17-8442-26b088e42f10

About this result

Related concepts (19)

Organometallic chemistry

Organometallic chemistry is the study of organometallic compounds, chemical compounds containing at least one chemical bond between a carbon atom of an organic molecule and a metal, including alkali, alkaline earth, and transition metals, and sometimes broadened to include metalloids like boron, silicon, and selenium, as well. Aside from bonds to organyl fragments or molecules, bonds to 'inorganic' carbon, like carbon monoxide (metal carbonyls), cyanide, or carbide, are generally considered to be organometallic as well.

Coupling reaction

In organic chemistry, a coupling reaction is a type of reaction in which two reactant molecules are bonded together. Such reactions often require the aid of a metal catalyst. In one important reaction type, a main group organometallic compound of the type R-M (where R = organic group, M = main group centre metal atom) reacts with an organic halide of the type R'-X with formation of a new carbon-carbon bond in the product R-R'. The most common type of coupling reaction is the cross coupling reaction. Richard F.

Insertion reaction

An insertion reaction is a chemical reaction where one chemical entity (a molecule or molecular fragment) interposes itself into an existing bond of typically a second chemical entity e.g.: The term only refers to the result of the reaction and does not suggest a mechanism. Insertion reactions are observed in organic, inorganic, and organometallic chemistry. In cases where a metal-ligand bond in a coordination complex is involved, these reactions are typically organometallic in nature and involve a bond between a transition metal and a carbon or hydrogen.