Assessing essentiality of transketolase in Mycobacterium tuberculosis using an inducible protein degradation system

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Gene therapy offers the possibility to treat or even cure diseases originating from genetic defects by introducing a therapeutic gene in target cells or correcting the initial defective gene. Amongst different options, non-viral vectors rely on the deliver ...

The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor in the SYSCOL cohort, we ...

DNA fragmentation is an essential process in developing genetic sequencing strategies, genetic research, as well as for the diagnosis of diseases with a genetic signature like cancer. Efficient on-chip DNA fragmentation protocols would be beneficial to pro ...

Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...

Fluorescent D-amino acids (FDAAs) have previ-ously been developed to enable in situ highlighting of locations of bacterial cell wall growth. Most bacterial cells lie at the edge of the diffraction limit of visible light; thus, resolving the precise details ...

Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in vitro and found that transcription fac ...

Natural competence for transformation is an important driver of horizontal DNA exchange between different organisms. This can result in accumulation of dangerous genetic features, such as antibiotic resistance genes, in a single organism. One example of an ...

Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one’s actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophr ...

Assessing essentiality of transketolase in Mycobacterium tuberculosis using an inducible protein degradation system

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Engineering of chitosan-based derivatives for non-viral gene delivery

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Bubble-enhanced ultrasonic microfluidic chip for rapid DNA fragmentation

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon

Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients