Assessing essentiality of transketolase in Mycobacterium tuberculosis using an inducible protein degradation system

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Mycobacterium Tuberculosis is a highly effective pathogen infecting nearly a third of the world's population. An M. tuberculosis infection starts when droplets containing bacteria enter an individual's lungs. The first host cells to contact the bacteria ar ...

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of specific MTBC genotypes to the respective human host population has been invoked in this context. We aim ...

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A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded 'mycobacterial ...

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

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Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outc ...

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Difficulties to replicate telomeres - the ends of our chromosomes - can cause telomere shortening and genome instability. These difficulties are due to the repetitive DNA sequence and distinct structures at telomeres that challenge the semi-conservative DN ...

Assessing essentiality of transketolase in Mycobacterium tuberculosis using an inducible protein degradation system

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Single-cell analysis of the interactions between Mycobacterium tuberculosis and macrophages

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

Human alveolar lining fl uid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction

Toward universal cell embeddings: integrating single-cell RNA-seq datasets across species with SATURN

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Screening for drivers of SARS-CoV-2 uptake

Neural ADMIXTURE for rapid genomic clustering

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Genetic features and genomic targets of human KRAB-zinc finger proteins

Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort

Biofilm morphogenesis on soft hydrogels

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

Archetypal Analysis for population genetics

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

Identification and characterization of proteins that protect human telomeres from fragility