Nanopore forming method and uses thereof

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GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020

Exploiting Errors for Efficiency: A Survey from Circuits to Applications

Babak Falsafi, Alexandros Daglis, Dorde Jevdic, Eva Darulova, Mattia Cacciotti

When a computational task tolerates a relaxation of its specification or when an algorithm tolerates the effects of noise in its execution, hardware, system software, and programming language compilers or their runtime systems can trade deviations from cor ...

ASSOC COMPUTING MACHINERY2020

Annealing and Replica-Symmetry in Deep Boltzmann Machines

Emanuele Mingione, Diego Alberici

In this paper we study the properties of the quenched pressure of a multi-layer spin-glass model (a deep Boltzmann Machine in artificial intelligence jargon) whose pairwise interactions are allowed between spins lying in adjacent layers and not inside the ...

SPRINGER2020

Private and Secure Distributed Learning

Georgios Damaskinos

The ever-growing number of edge devices (e.g., smartphones) and the exploding volume of sensitive data they produce, call for distributed machine learning techniques that are privacy-preserving. Given the increasing computing capabilities of modern edge de ...

EPFL2020

On-Chip Fully Integrated Field Emission Arrays for High-Voltage MEMS Applications

Vivek Subramanian

Vacuum-sealed fully integrated diode and triode field emission arrays based on Ti Spindt-type field emitters have been developed in a scalable, CMOS-compatible process directly on Si. Diode characterization in air demonstrates effective vacuum sealing and ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

Aerolysin, a Powerful Protein Sensor for Fundamental Studies and Development of Upcoming Applications

Françoise Gisou van der Goot Grunberg

The nanopore electrical approach is a breakthrough in single molecular level detection of particles as small as ions, and complex as biomolecules. This technique can be used for molecule analysis and characterization as well as for the understanding of con ...

AMER CHEMICAL SOC2019

Intracellular Recording of Cardiomyocyte Action Potentials with Nanopatterned Volcano-Shaped Microelectrode Arrays

Philippe Renaud, Arnaud Bertsch, Benoît Xavier Emmanuel Desbiolles

Micronanotechnology-based multielectrode ar- rays have led to remarkable progress in the field of transmembrane voltage recording of excitable cells. However, providing long-term optoporation- or electroporation-free intracellular access remains a consider ...

American Chemical Society (ACS)2019

A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family

Henry Markram, Rajnish Ranjan, Emmanuelle Logette, Enrico Scantamburlo, Michela Marani, Valérie Buchillier, Mirjia Herzog

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully sequenced decades ago, a comprehensive kinetic characterization of al ...

2019

Single crystalline diamond diffractive optical elements and method of fabricating the same

Niels Quack, Teodoro Graziosi, Marcell Kristof Kiss

The present invention concerns a single crystalline diamond optical element production method. The method includes the steps of: ‐ providing a single crystalline diamond substrate or layer; ‐ applying a mask layer to the single crystalline diamond substrat ...

2019