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Publication

Nanopore forming method and uses thereof

Aleksandra Radenovic, Ke Liu, Jiandong Feng
2016
Patents

Abstract

Method for making nanopores in thin layers or monolayers of transition metal dichalcogenides comprising the steps of provinding a suspended transistion metal dichalcogenide layer (1) in an electrolyte (2), applying a transmembrane voltage (V) high enough to lead to the breakdown of the layer (1), monitoring the ionic current (Ii) and reducing the transmembrane voltage (V) when the ionic current (Ii) has reached a predefined cut-off value (Ip).

Official source

https://infoscience.epfl.ch/entities/publication/fb47655d-2eda-4e4d-94db-2a00dbfb245a

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Aleksandra Radenovic, Ke Liu, Jiandong Feng
2016
Patents

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/fb47655d-2eda-4e4d-94db-2a00dbfb245a

About this result

Related concepts (17)

Membrane potential

Membrane potential (also transmembrane potential or membrane voltage) is the difference in electric potential between the interior and the exterior of a biological cell. That is, there is a difference in the energy required for electric charges to move from the internal to exterior cellular environments and vice versa, as long as there is no acquisition of kinetic energy or the production of radiation. The concentration gradients of the charges directly determine this energy requirement.

Voltage-gated ion channel

Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the electrical membrane potential near the channel. The membrane potential alters the conformation of the channel proteins, regulating their opening and closing. Cell membranes are generally impermeable to ions, thus they must diffuse through the membrane through transmembrane protein channels. They have a crucial role in excitable cells such as neuronal and muscle tissues, allowing a rapid and co-ordinated depolarization in response to triggering voltage change.

Voltage-gated potassium channel

Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential. During action potentials, they play a crucial role in returning the depolarized cell to a resting state. Alpha subunits form the actual conductance pore. Based on sequence homology of the hydrophobic transmembrane cores, the alpha subunits of voltage-gated potassium channels are grouped into 12 classes. These are labeled Kvα1-12.

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Nanopore forming method and uses thereof

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