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Publication

High-Performance Protein Preconcentrator Using Microchannel-Integrated Nafion Strip

Martinus Adela Maria Gijs, Venkataragavalu Sivagnanam, Hui Yang, Meng Shen
2011
Conference Papers

Abstract

A microfluidic device for protein preconcentration based on the electrokinetic trapping principle is proposed. It comprises a Nafion strip which is simply cut from a commercially available membrane and integrated into a polydimethylsiloxane (PDMS) microfluidic structure using a guiding channel. By applying low voltage (1000 of fluorescently labeled bovine serum albumin (BSA) within a few minutes. Moreover, a numerical study of the preconcentration effect is presented to microscopically understand the phenomenon in our type of device.

Official source

https://infoscience.epfl.ch/entities/publication/f4f68cbf-bef3-45cd-a2da-b8117507489d

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Martinus Adela Maria Gijs, Venkataragavalu Sivagnanam, Hui Yang, Meng Shen
2011
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/f4f68cbf-bef3-45cd-a2da-b8117507489d

About this result

Related concepts (13)

Microfluidics

Microfluidics refers to a system that manipulates a small amount of fluids ((10−9 to 10−18 liters) using small channels with sizes ten to hundreds micrometres. It is a multidisciplinary field that involves molecular analysis, biodefence, molecular biology, and microelectronics. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening.

Droplet-based microfluidics

Droplet-based microfluidics manipulate discrete volumes of fluids in immiscible phases with low Reynolds number and laminar flow regimes. Interest in droplet-based microfluidics systems has been growing substantially in past decades. Microdroplets offer the feasibility of handling miniature volumes (μl to fl) of fluids conveniently, provide better mixing, encapsulation, sorting, sensing and are suitable for high throughput experiments.

Paper-based microfluidics

Paper-based microfluidics are microfluidic devices that consist of a series of hydrophilic cellulose or nitrocellulose fibers that transport fluid from an inlet through the porous medium to a desired outlet or region of the device, by means of capillary action. This technology builds on the conventional lateral flow test which is capable of detecting many infectious agents and chemical contaminants. The main advantage of this is that it is largely a passively controlled device unlike more complex microfluidic devices.

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