Publications related to Aging biomarkers

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Recent research shows prominent effects of pregnancy and the parenthood transition on structural brain characteristics in humans. Here, we present a comprehensive study of how parental status and number of children born/fathered links to markers of brain a ...

Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We c ...

Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...

The world's population is aging at an increasing rate. Even in the absence of neurodegenerative disorders, healthy aging affects perception and cognition. In the context of cognition, common factors are well established. Much less is known about common fac ...

Autophagy is a highly conserved process by which long-lived macromolecules, protein aggregates and dysfunctional/damaged organelles are delivered to lysosomes for degradation. Autophagy plays a crucial role in regulating protein quality control and cell ho ...

In this work, the uniaxial creep in compression during the first days of hydration is studied experimentally on cement pastes with w/c of 0.50. to order to assess the effect of the evolving microstructure on creep, the so-called equivalent systems are empl ...

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

Aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually found that older participants perform worse than younger participants. Implicitly, these results are taken a ...

The microbiome has been demonstrated to play an integral role in the maintenance of many aspects of health that are also associated with aging. In order to identify areas of potential exploration and intervention, we simultaneously characterized age-relate ...

The developed world is aging faster than ever before. Even in the absence of neurodegenerative disease, aging affects all kinds of human functions including perception and cognition. In most perceptual studies, one paradigm is tested and it is usually foun ...

Falls are one of the most serious problems in the elderly. Although previous studies clearly link the increased risk of falls with ageing, the mechanisms responsible for the modifications of reactive motor behaviours in response to external perturbations a ...

Discovered in the beginning of the 20(th) century, nicotinamide adenine dinucleotide (NAD(+)) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD ...

Objective: Augmenting nicotinamide adenine dinucleotide (NAD(+)) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD(+) precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appe ...

Even in the absence of neurodegenerative disease, aging strongly affects vision. Whereas optical deficits are well documented, much less is known perceptual deficits. In most perceptual studies, one paradigm is tested and it is usually found that older par ...

Ageing affects many visual functions. Here, we investigated the effects of ageing on vernier acuity and backward masking using the shine-through paradigm. We divided healthy older adults (> 60 years) into two groups depending on whether vernier duration wa ...

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

This work validates the use of integrated polyvinylidene fluoride (PVDF) film sensors for dynamic testing, even after being subjected to UV-thermo-hygro-mechanical accelerated ageing conditions. The verification of PVDF sensors' survivability in these envi ...

Aging biomarkers

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Parental status and markers of brain and cellular age: A 3D convolutional network and classification study

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Cross-species functional modules link proteostasis to human normal aging

No Evidence for a Common Factor Underlying Visual Abilities in Healthy Older People

Autophagy and LRRK2 in the Aging Brain

Basic creep of cement paste at early age - the role of cement hydration

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Multi-factorial approach in aging research

Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

Multi-factorial approach in aging research

Stability against backward balance loss: Age-related modifications following slip-like perturbations of multiple amplitudes

Modulating NAD(+) metabolism, from bench to bedside

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

Is there a common cause for perceptual decline in the aging brain?

The effects of aging on perception and cognition

Aging and perception

Ageing and visual spatiotemporal processing

Mitochondrial ribosomal proteins as aging regulators

Survivability of integrated PVDF film sensors to accelerated ageing conditions in aeronautical/aerospace structures