Publication

Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative

Pierre Vogel
1999
Journal Articles

Abstract

(-)-(3aS,5S,6S,6aR)-3a,5,6,6a-Tetrahydro-5, 6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol ((-)-5) has been tested toward 25 glycohydrolases and found to inhibit beta-galactosidase from Aspergillus niger (K-i = 18 mu M) and that from Aspergillus orizae (K-i = 72 mu M) Hydrolysis of the acetonide or exchange of CH2OH group for a CHO, CH2OMe or a CH2OMOM group suppresses the inhibitory activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

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Pierre Vogel
1999
Journal Articles

Abstract

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