Publication

ALT Telomeres Get Together with Nuclear Receptors

Joachim Lingner, Eric Aeby
2015
Journal Articles

Abstract

Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere insertions (TTI).

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ALT Telomeres Get Together with Nuclear Receptors

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