Publication

Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis

Viesturs Simanis
2007
Journal Articles

Abstract

Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts.

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Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis

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