Toward an Effective Control of DNA's Submolecular Conformation on a Surface

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DNA mechanics plays a crucial role in many biological processes, including nucleosome positioning and protein-DNA interactions. It is believed that nature employs epigenetic modifications in DNA to further regulate gene expression. Moreover, double-strande ...

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DNA-binding proteins physically interact with the DNA and directly affect genomic functions. The eukaryotic genome is compacted into chromatin, limiting the DNA access to nuclear factors. In this Ph.D. thesis, I explored the dynamic mechanisms, that allow ...

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The local physical properties - such as shape and flexibility - of the DNA double-helix is today widely believed to be influenced by nucleic acid sequence in a non-trivial way. Furthermore, there is strong evidence that these properties play a role in many ...

Next-generation sequencing (NGS) is an essential technology for DNA identification in genomic research. DNA fragmentation is a critical step for NGS and doing this on-chip is of great interest for future integrated genomic solutions. Here we demonstrate fa ...

DNA fragmentation is an essential process in developing genetic sequencing strategies, genetic research, as well as for the diagnosis of diseases with a genetic signature like cancer. Efficient on-chip DNA fragmentation protocols would be beneficial to pro ...

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Biologically inspired solid-state nanopores are artificial openings or apertures in thin membranes similar to natural protein ion channels in a lipid bilayer of cell membranes. In solid-state nanopores, a thin insulating membrane with single or multiple po ...

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The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational ch ...

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Toward an Effective Control of DNA's Submolecular Conformation on a Surface

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Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

cgNA+: A sequence-dependent coarse-grain model of double-stranded nucleic acids

A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical surveying and monitoring

Development of multiplexed single-molecule imaging techniques to study chromatin invasion dynamics of chromatin effector proteins

Achieving high hybridization density at DNA biosensor surfaces using branched spacer and click chemistry

Landscapes of DNA Mechanics and Genomes

Polydimethylsiloxane microstructure-induced acoustic streaming for enhanced ultrasonic DNA fragmentation on a microfluidic chip

Bubble-enhanced ultrasonic microfluidic chip for rapid DNA fragmentation

Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon

2D MoS2 Nanopores: Wafer-scale Fabrication and Monolayer Stability for Long-term Single-Molecule Sensing

Electrochemical and morphological engineering of 2D materials for nanopore sensing

Structural and Photophysical Templating of Conjugated Polyelectrolytes with Single-Stranded DNA

Structural and DNA binding properties of mycobacterial integration host factor mIHF

Optimised biomolecular extraction for metagenomic analysis of microbial biofilms from high-mountain streams

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

Directed evolution of DNA-wrapped single-walled carbon nanotube complexes for optical sensing

Fundamental Applications of Nanopores: Controlled DNA Translocations to Nanofluidics

Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?

Computational study of transcription factor binding sites

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic