Publications related to Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

Related publications (10)

Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos

Denis Duboule, Lucille Delisle, Alexandre Gauthier Aurèle Mayran, Dominique Anne Sarah Kolly

Understanding the interplay between cell fate specification and morphogenetic changes remains a challenge in developmental biology. Gastruloids, stem cell models of postimplantation mammalian development, provide a platform to address this question. Here, ...

American Association for the Advancement of Science (AAAS)2025

Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence

Agnieszka Alicja Chryplewicz

Glioblastoma recurrence is currently inevitable despite extensive standard-of-care treatment. In preclinical studies, an alternative strategy of targeting tumor-associated macrophages and microglia through CSF-1R inhibition was previously found to regress ...

CELL PRESS2024

Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes

Henry Markram, Daniel Keller, Jay Coggan, Polina Shichkova

The regulation of energy in the brain has garnered substantial attention in recent years due to its significant implications in various disorders and aging. The brain’s energy metabolism is a dynamic and tightly regulated network that balances energy deman ...

MDPI AG2024

Editorial: Regional and molecular fingerprint of adipogenesis in aging and disease

Josefine Catharina Pedersen Tratwal

FRONTIERS MEDIA SA2023

Multiscale X-ray imaging and characterisation of pharmaceutical dosage forms

Marianne Liebi

A correlative, multiscale imaging methodology for visualising and quantifying the morphology of solid dosage forms by combining ptychographic X-ray computed nanotomography (PXCT) and scanning small- and wide-angle X-ray scattering (S/WAXS) is presented. Th ...

ELSEVIER2023

PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Carole Poitry-Yamate, Dunja Simicic, Jessie Julie Mosso, Mario Gaetano Lepore, Ting Yin

Type C hepatic encephalopathy (HE) is a complex neuropsychiatric disorder occurring as a consequence of chronic liver disease. Alterations in energy metabolism have been suggested in type C HE, but in vivo studies on this matter remain sparse and have repo ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses

Inès Mariam Castarède

Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ phy ...

2021

The Brain Connectome after Gamma Knife Radiosurgery of the Ventro-Intermediate Nucleus for Tremor: Marseille-Lausanne Radiobiology Study Protocol

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Constantin Tuleasca

Essential tremor (ET) is the most common movement disorder. Deep brain stimulation is the current gold standard for drug-resistant tremor, followed by radiofrequency lesioning. Stereotactic radiosurgery by Gamma Knife (GK) is considered as a minimally inva ...

2021

Combination of neonatal porcine islets with mesenchymal stem cells of human and porcine origin improves islet function

Sandrine Gerber, Luca Szabó

WILEY2019

Brain technologies raise unprecedented ethical challenges

Olaf Blanke, Jane Aspell

Nature Publishing Group2009