Publication

Normative brain atlas of T2/T1 relaxometry ratio for detection of microstructural pathology

Jean-Philippe Thiran
2023

Abstract

Quantitative MRI allows the characterization and comparison of microstructural tissue properties and, by defining normative ranges for healthy tissue, detection of pathology. The simultaneous evaluation of multiple qMRI measures facilitates the understanding of what biological mechanisms underlie the observed deviations in relaxometry. Here, we introduce the ratio between quantitative T2 and T1 maps (T2/T1) as a microstructural property whose deviations from normative values could be predictive or characteristic of brain pathologies. A T2/T1 voxel-wise normative atlas was created and allowed characterization of tissue changes in two multiple sclerosis patients, providing complementary information to the existing T1 and T2 atlases.

Official source

https://infoscience.epfl.ch/entities/publication/df5695ec-9eed-49d8-8491-c2695d6a7c3f

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Jean-Philippe Thiran
2023

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/df5695ec-9eed-49d8-8491-c2695d6a7c3f

About this result

Related concepts (30)

Magnetic resonance imaging

Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from computed tomography (CT) and positron emission tomography (PET) scans.

Standard deviation

In statistics, the standard deviation is a measure of the amount of variation or dispersion of a set of values. A low standard deviation indicates that the values tend to be close to the mean (also called the expected value) of the set, while a high standard deviation indicates that the values are spread out over a wider range. Standard deviation may be abbreviated SD, and is most commonly represented in mathematical texts and equations by the lower case Greek letter σ (sigma), for the population standard deviation, or the Latin letter s, for the sample standard deviation.

Deviation (statistics)

In mathematics and statistics, deviation is a measure of difference between the observed value of a variable and some other value, often that variable's mean. The sign of the deviation reports the direction of that difference (the deviation is positive when the observed value exceeds the reference value). The magnitude of the value indicates the size of the difference. Errors and residuals A deviation that is a difference between an observed value and the true value of a quantity of interest (where true value denotes the Expected Value, such as the population mean) is an error.

Related publications (2)

Normative brain atlas of T2/T1 relaxometry ratio for detection of microstructural pathology

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