Inactivation of brain Cofilin-1 by age, Alzheimer's disease and gamma-secretase

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In humans, mice, and other mammals key internal organs such as the gut, the lungs, the pancreas, and the liver all derive from the same embryonic tissue: the endoderm. The development of all of these structures thus depends on a same set of early cells, an ...

Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify defici ...

Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...

Motor skill acquisition is essential to our survival, as it enables an efficient interaction with the changing world around us. The acquisition of novel sequential tasks, of particular relevance due to their pervasiveness in everyday life activities, can b ...

The relationship between age-related changes in brain structural connectivity (SC) and functional connectivity (FC) with cognition is not well understood. Furthermore, it is not clear whether cognition is represented via a similar spatial pattern of FC and ...

Many neurodegenerative diseases are associated with the death of specific neuron types in particular brain regions. What makes the death of specific neuron types particularly harmful for the integrity and dynamics of the respective network is not well unde ...

Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...

Chromatin compartmentalization reflects biological activity. However, inference of chromatin sub-compartments and compartment domains from chromosome conformation capture (Hi-C) experiments is limited by data resolution. As a result, these have been charac ...

Organoids are powerful models for studying tissue development, physiology, and disease. However, current culture systems disrupt the inductive tissue-tissue interactions needed for the complex morphogenetic processes of native organogenesis. Here, we show ...

An important function of the brain is to analyze sensory information, and to modulate animal behaviour according to previous experience. During processes of emotional learning, sensory percepts with a reinforcing quality, also called unconditioned stimuli ...

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and gamma-secretase

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In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

Epigenetic plasticity as a signature for memory allocation

The aging brain as a model to understand motor skill acquisition in humans and its restoration using non-invasive brain stimulation

Mapping of Structure-Function Age-Related Connectivity Changes on Cognition Using Multimodal MRI

The Role of Hub Neurons in Modulating Cortical Dynamics

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes

Capturing Cardiogenesis in Gastruloids

Target cell-type specificity of a cortico-amygdala long range synaptic connection