Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

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Neural interfaces are devices that are implanted into the body and interface electrically with the central (CNS) or peripheral nervous system. They are inserted surgically for short periods of time or chronically to diagnose or treat several neural disease ...

Patella-related complications after total knee arthroplasty (TKA) remain a major clinical concern. Previous studies have suggested that increased postoperative patellar bone strain could be related to such complications, but there is limited knowledge on p ...

Spinal cord injury (SCI) disrupts communication within central nervous system and lead to range of neurological disorders including paralysis. Current rehabilitation strategies to restore locomotion are poorly effective in people with severe SCI. Epidural ...

The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and he ...

Understanding the interactions between biomedical alloys and body fluids is of importance for the successful and safe performance of implanted devices. Albumin, as the first protein that comes in contact with an implant surface, can determine the biocompat ...

Over the last decade, active lower-limb prostheses demonstrated their ability to restore a physiological gait for transfemoral amputees by supplying the required positive energy balance during daily life locomotion activities. However, the added-value of s ...

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyele ...

Bipedal locomotion is a remarkable feature of humans. This skill is necessary for the activities of daily living. Unfortunately, many people only partially benefit from it or miss it entirely because of a disability. This may result in a slower gait, less ...

Objective: Despite recent advances in pharmacological research and microsurgery, lymphoedema remains an incurable disease that deeply affects quality of life. There is an urgent need for innovative approaches to restore continuous lymph flow in affected ti ...

The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strategies for BM-rela ...

Objective: In this paper, a new vibrational modal analysis technique was developed for intraoperative cementless prosthesis fixation evaluation upon hammering. Methods: An artificial bone (Sawbones)-prosthesis system was excited by sweeping of a sine signa ...

To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...

Knee implant loosening is mainly caused by the weakness of the prosthesis-bone interface and is the main reason for surgical revisions. However, pre-operative diagnosis is difficult due to lack of accurate tests. In this study, we developed a vibration-bas ...

Biocompatibility is one of the biggest challenges for biomaterials development. This issue arises in the case of coatings. Calcium phosphate (CP) coatings are currently used to cover femoral stem implants, while calcium titanate (CT) has also been proposed ...

BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...

Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration

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Integration of hybrid material systems in conformable neural interfaces

Patellar bone strain after total knee arthroplasty is correlated with bone mineral density and body mass index

Spatiotemporal stimulation strategies in neuroprostheses to improve locomotion after spinal cord injury

Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications

An Overview of Serum Albumin Interactions with Biomedical Alloys

Bio-inspired design and validation of the Efficient Lockable Spring Ankle (ELSA) prosthesis

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Control Strategies for Lower-limb Exoskeletons: from Full Mobilization to Assistance of Balance

Experimental Drainage Device to Reduce Lymphoedema in a Rat Model

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

A Vibrational Technique for in vitro Intraoperative Prosthesis Fixation Monitoring

Sub-trabecular strain evolution in human trabecular bone

Knee Implant Loosening Detection: A Vibration Analysis Investigation

Fretting corrosion between bone and calcium phosphate-calcium titanate coatings

Non-setting, injectable biomaterials containing particulate hydroxyapatite can increase primary stability of bone screws in cancellous bone