Nicotine increases sleep spindle activity

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Universal inference enables the construction of confidence intervals and tests without regularity conditions by splitting the data into two parts and appealing to Markov's inequality. Previous investigations have shown that the cost of this generality is a ...

Important brainstem regions are involved in the regulation of rapid eye movement sleep. We hypothesized that brainstem stroke is associated with dysregulated rapid eye movement sleep and related muscle activity. We compared quantitative/qualitative polysom ...

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Functional dissociations in the brain observed during non-rapid eye movement (NREM) sleep have been associated with reduced information integration and impaired consciousness that accompany increasing sleep depth. Here, we explored the dynamical properties ...

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The k(off) values of ligands unbinding to proteins are key parameters for drug discovery. Their predictions based on molecular simulation may under- or overestimate experiment in a system- and/or technique-dependent way. Here we use an established method-i ...

Background: Nicotinamide riboside (NR) is an NAD(+) precursor that boosts cellular NAD(+) concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. ...

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

The cholinergic system is known to strongly modulate perceptual and cognitive processes, and the alpha7 subunit of the cholinergic nicotinic receptor (CHRNA7) is broadly expressed within the visual system. Here, we assessed whether genetic variations of CH ...

Nicotine increases sleep spindle activity

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Anthony C Davison and Igor Rodionov's contribution to the Discussion of 'Estimating means of bounded random variables by betting' by Waudby-Smith and Ramdas

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