Directed evolution of the optoelectronic properties of synthetic nanomaterials

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While widespread genome sequencing ushers in a new era of preventive medicine, the tools for predictive genomics are still lacking. Time and resource limitations mean that human diseases remain uncharacterized because of an inability to predict clinically ...

Background Inherited optic neuropathies (IONs) cover a spectrum of clinically and genetically heterogenic conditions. Genetic evaluation of patients with IONs may enable their better clinico-diagnostic assessment and management of the disease. The aim of t ...

Inherited retinal dystrophies (IRDs) are a large and heterogeneous group of degenerative diseases caused by mutations in various genes. Given the favorable anatomical and immunological characteristics of the eye, gene therapy holds great potential for thei ...

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The susceptibility of waterborne viruses to different inactivating treatments is acknowledged to vary between viruses and even between closely related strains, yet the extent of this variation, or the underlying mechanisms, are not known. Here, different e ...

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Epigenetics plays an important role in cancer development and progression. Cancer cells hijack the epigenome by modifying the histone protein units responsible for packaging DNA, or by modifying the DNA itself, resulting in changes to chromatin topology an ...

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Directed evolution of the optoelectronic properties of synthetic nanomaterials

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Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity

Predicting the Occurrence of Variants in RAG1 and RAG2

Analysis of Inherited Optic Neuropathies

Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-alpha 7 mediated nuclear import pathway

Susceptibility of Enterovirus B strains to disinfectants and heat

Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen

A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer

Mutations in the polyglutamylase geneTTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility

IROme, a New High-Throughput Molecular Tool for the Diagnosis of Inherited Retinal Dystrophies