Publication

Statistical Inference in Positron Emission Tomography

2014
Student Projects

Abstract

In this report, we investigate mathematical algorithms for image reconstruction in the context of positron emission tomography (a medical diagnosis technique). We first take inspiration from the physics of PET to design a mathematical model tailored to the problem. We think of positron emissions as an output of an indirectly observed Poisson process and formulate the link between the emissions and the scanner records through the Radon transform. This model allows us to express the image reconstruction in terms of a standard problem in statistical estimation from incomplete data. Then, we investigate different algorithms as well as stopping criterion, and compare their relative efficiency.

Official source

https://infoscience.epfl.ch/entities/publication/cb147787-cb9f-40a4-a13a-3454377fd0b1

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2014
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/cb147787-cb9f-40a4-a13a-3454377fd0b1

About this result

Related concepts (32)

Positron emission tomography

Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example, -FDG is commonly used to detect cancer, NaF is widely used for detecting bone formation, and oxygen-15 is sometimes used to measure blood flow.

Statistical model

A statistical model is a mathematical model that embodies a set of statistical assumptions concerning the generation of sample data (and similar data from a larger population). A statistical model represents, often in considerably idealized form, the data-generating process. When referring specifically to probabilities, the corresponding term is probabilistic model. A statistical model is usually specified as a mathematical relationship between one or more random variables and other non-random variables.

Statistical inference

Statistical inference is the process of using data analysis to infer properties of an underlying distribution of probability. Inferential statistical analysis infers properties of a population, for example by testing hypotheses and deriving estimates. It is assumed that the observed data set is sampled from a larger population. Inferential statistics can be contrasted with descriptive statistics. Descriptive statistics is solely concerned with properties of the observed data, and it does not rest on the assumption that the data come from a larger population.

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