Whole-genome doubling drives oncogenic loss of chromatin segregation

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Telomeres are the nucleoprotein structures found at the ends of linear chromosomes. They ensure that the termini of chromosomes are not inappropriately recognized as sites of DNA damage, and are therefore crucial for genome stability. In spite of the heter ...

Regulation of gene expression is a complex but highly guided process. While genomic technologies and computational approaches have allowed high-throughput mapping of cis-regulatory elements (CREs) and their interactions in 3D, their precise role in regulat ...

DNA-binding proteins physically interact with the DNA and directly affect genomic functions. The eukaryotic genome is compacted into chromatin, limiting the DNA access to nuclear factors. In this Ph.D. thesis, I explored the dynamic mechanisms, that allow ...

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Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...

Background: Cancer genome sequencing enables accurate classification of tumours and tumour subtypes. However, prediction performance is still limited using exome-only sequencing and for tumour types with low somatic mutation burden such as many paediatri ...

Co-expression of two or more genes at the single-cell level is usually associated with functional co-regulation. While mRNA co-expression-measured as the correlation in mRNA levels-can be influenced by both transcriptional and post-transcriptional events, ...

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Background Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early and late pubertal onset are both associated with various diseases developing later in life, and epigenetic c ...

Whole-genome doubling drives oncogenic loss of chromatin segregation

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Regulation and impact of TERRA R-loops at human telomeres

Chromatin modules and their implication in genomic organization and gene regulation

Development of multiplexed single-molecule imaging techniques to study chromatin invasion dynamics of chromatin effector proteins

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping

Exploring the role of transcriptional and post-transcriptional processes in mRNA co-expression

CENP-A and CENP-B collaborate to create an open centromeric chromatin state

Centromere structure and function: lessons from Drosophila

DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study