Intrafascicular electrode implant

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This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

Background Each year, five million people are left disabled after stroke. Upper -extremity (UE) dysfunction is a leading problem. Neuroplasticity can be enhanced by non-invasive brain stimulation (NIBS) but evidence from large, randomized multicenter trial ...

A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

Herein, machine learning (ML) models using multiple linear regression (MLR), support vector regression (SVR), random forest (RF) and artificial neural network (ANN) are developed and compared to predict the output features viz. specific capacitance (Csp), ...

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

BackgroundOpen reduction and plate osteosynthesis are considered as a successful technique for the treatment of proximal humerus fracture (PHF) despite high complication rates. The objective of our study was to review the clinical outcome and complications ...

"Ensure healthy lives and promote well-being for all at all ages" is the third sustainable development goal for the United Nations Agenda of 2030. This doctoral thesis fully embodied this objective by targeting stroke, a leading cause of death and disabili ...

Objective. Intraneural nerve interfaces often operate in a monopolar configuration with a common and distant ground electrode. This configuration leads to a wide spreading of the electric field. Therefore, this approach is suboptimal for intraneural nerve ...

Precise control of bionic limbs relies on robust decoding of motor commands from nerves or muscles signals and sensory feedback from artificial limbs to the nervous system by interfacing the afferent nerve pathways. Implantable devices for bidirectional co ...

We propose a novel machine learning (ML)-driven methodology to estimate biomechanical variables of interest traditionally obtained from upper-extremity musculoskeletal (MSK) modeling. MSK models facilitate personalized modeling, perform "what-if" analyses, ...

Objectives (i) to create a shortened version of the Action Research Arm Test scale, (ii) to investigate its psychometric properties compared to the original scale and (iii) to externally validate it within an independent cohort. Design Prospective longitud ...

Context Long-term adherence to physical activity (PA) interventions is challenging. The Lifestyle-integrated Functional Exercise programmes were adapted Lifestyle-integrated Functional Exercise (aLiFE) to include more challenging activities and a behaviour ...

Technological progress in materials science and microengineering along with new discoveries in neuroscience have contributed to restore lost or impaired sensory functions by closely interfacing with the nervous system. Electronic devices have begun to be i ...

Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentia ...

Although hallucinations are important and frequent symptoms in major psychiatric and neurological diseases, little is known about their brain mechanisms. Hallucinations are unpredictable and private experiences, making their investigation, quantification a ...

Transient electronics enabling devices to safely disappear in the environment can be applied not only in green electronics, but also in bioelectronic medicine. Neural implants able to degrade harmlessly inside the body eliminate the need for removal surger ...

A flow directed device adapted to be guided by a fuid, such as blood, flow within a tubular structure such as a blood vessel is disclosed, said device comprising a proximal end (100), a distal end (101) and an elongated body (102) in between defining a lon ...

Neural regeneration after lesions is still limited by several factors and new technologies are developed to address this issue. Here, we present and test in animal models a new regenerative nerve cuff electrode (RnCE). It is based on a novel low-cost fabri ...

Intrafascicular electrode implant

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Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Efficacy and safety of transcranial direct current stimulation to the ipsilesional motor cortex in subacute stroke (NETS): a multicenter, randomized, double-blind, placebo-controlled trial

A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Machine learning models for prediction of electrochemical properties in supercapacitor electrodes using MXene and graphene nanoplatelets

Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Comparison of the ALPS and PHILOS plating systems in proximal humeral fracture fixation - a retrospective study

Combination of Neurotechnologies Towards Personalized Neurorehabilitation for Stroke Patients

Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation

Bidirectional bionic limbs: a perspective bridging technology and physiology

Machine Learning for Musculoskeletal Modeling of Upper Extremity

Evaluation of a shortened version of the Action Research Arm Test (ARAT) for upper extremity function after stroke: The Mini-ARAT

Impact of adherence to a lifestyle-integrated programme on physical function and behavioural complexity in young older adults at risk of functional decline: a multicentre RCT secondary analysis

Fabrication and validation of an intraneural interface tailored for optic nerve stimulation

Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper

Neuroscience robotics for controlled induction and real-time assessment of hallucinations

Development of a Transient Neural Interface for Minimally Invasive Recording and Stimulation

Ultraflexible flow directed device and system

All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes