Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

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Recently, single-particle cryo-electron microscopy emerged as a technique capable of determining protein structures at near-atomic resolution and resolving protein dynamics with a temporal resolution ranging from second to milliseconds. This thesis describ ...

Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...

Microsecond time-resolved cryo-electron microscopy has emerged as a novel approach for directly observing protein dynamics. By providing microsecond temporal and near-atomic spatial resolution, it has the potential to elucidate a wide range of dynamics tha ...

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Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor

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From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

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Microsecond time-resolved cryo-electron microscopy

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Artificial intelligence for natural product drug discovery

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Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

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Advancing first principle-based molecular dynamics of biological systems with machine learning

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Computer-implemented design of peptide:receptor signaling complexes for enhanced chemotaxis

Bridging Native and Intrinsic Structures of Microhydrated Biomolecules by Cold Ion Spectroscopy