Exploiting Ligand-Protein Conjugates to Monitor Ligand-Receptor Interactions

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Current imaging technologies are limited in their capability to simultaneously capture intracellular and extracellular dynamics in a spatially and temporally resolved manner. This study presents a multimodal imaging system that integrates nanoplasmonic sen ...

The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...

Quantum Field Theories are a central object of interest of modern physics, describing fundamental interactions of matter. However, current methods give limited insight into strongly coupling theories. S-matrix bootstrap program, described in this thesis, a ...

G-protein-coupled receptors (GPCRs) are key regulators of human physiology and are the targets of many small-molecule research compounds and therapeutic drugs. While most of these ligands bind to their target GPCR with high affinity, selectivity is often l ...

The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

Combining superconducting resonators and quantum dots has triggered tremendous progress in quantum information, however, attempts at coupling a resonator to even charge parity spin qubits have resulted only in weak spin-photon coupling. Here, we integrate ...

Proteins are foundational biomolecules of life playing a crucial role in a myriad of biological processes. Their function often requires interplay with other biomolecules, including proteins themselves. Protein-protein interactions (PPIs) are essential for ...

Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...

The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calcu ...

Investigating the dynamic activities of protein expression and signaling in living organisms is a crucial focus of intense research aimed at elucidating the processes that underlie disease progression and improving treatments and drug development. Resolvin ...

A search for new physics in final states consisting of at least one photon, multiple jets, and large missing transverse momentum is presented, using proton-proton collision events at a center-of-mass energy of 13 TeV. The data correspond to an integrated l ...

A density wave (DW) is a fundamental type of long-range order in quantum matter tied to self-organization into a crystalline structure. The interplay of DW order with superfluidity can lead to complex scenarios that pose a great challenge to theoretical an ...

The charge-parity (CP) structure of the Yukawa interaction between the Higgs (H) boson and the top quark is measured in a data sample enriched in the t (t) over bar H and tH associated production, using 138 fb(-1) of data collected in proton-proton collisi ...

This thesis reports on the realization of the first experiments conducted with superfluid, strongly interacting Fermi gases of 6Li coupled to the light field of an optical cavity. In the scope of existing ultracold atomic platforms, this is the first time ...

We investigate and characterize the emergence of finite-component dissipative phase transitions (DPTs) in nonlinear photon resonators subject to n-photon driving and dissipation. Exploiting a semiclassical approach, we derive general results on the occurre ...

Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus's spike protein and ce ...

In this Letter, we address the question of whether the conformal invariance can be considered as a global symmetry of a theory of fundamental interactions. To describe Nature, this theory must contain a mechanism of spontaneous breaking of the scale symmet ...

Nowadays, as a result of the emergence of low-dimensional hybrid structures, the scientific community is interested in their interfacial carrier dynamics, including charge transfer and energy transfer. By combining the potential of transition metal dichalc ...

Otoliths are calcium carbonate components of the stato-acoustical organ responsible for hearing and maintenance of the body balance in teleost fish. During their formation, control over, e.g., morphology and carbonate polymorph is influenced by complex ins ...

Exploiting Ligand-Protein Conjugates to Monitor Ligand-Receptor Interactions

Chat with Graph Search

Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single-Cell Secretory and Intracellular Dynamics

Improved microfluidic transcriptome based screening methods

Bootstrapping amplitudes of scalar particles

Antibodies expand the scope of angiotensin receptor pharmacology

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Strong coupling between a microwave photon and a singlet-triplet qubit

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

Mechanisms and functions of protein S-acylation

Opportunities and challenges in design and optimization of protein function

Label-free plasmonic microarray for multiplexed analysis of cells and tumor organoids

Search for new physics in multijet events with at least one photon and large missing transverse momentum in proton-proton collisions at 13 TeV

Density-wave ordering in a unitary Fermi gas with photon-mediated interactions

Search for CP violation in t(t)over-bar H and tH production in multilepton channels in proton-proton collisions at √s=13 TeV

Many-body physics with strongly interacting fermions coupled to light

Dissipative phase transitions in n-photon driven quantum nonlinear resonators

De novo designed proteins: a study in engineering novel folds and functions

Screening for drivers of SARS-CoV-2 uptake

Anomaly-free scale symmetry and gravity

Energy transfer and charge transfer between semiconducting nanocrystals and transition metal dichalcogenide monolayers

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host