Publication

Reconciliation of classification systems defining molecular subtypes of colorectal cancer

Related publications (27)

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Michel Aguet, Mauro Delorenzi, Norbert Wiedemann, Sylvie André Baflast, Pascale Anderle Pedone, Frédérique Baruthio, Andreas Eduard Moor, Patrick Rodriguez

BCL9/9L proteins enhance the transcriptional output of the beta-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9 ...

Elsevier Science Bv2015

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Mauro Delorenzi, Nadine Fournier, Stavros Milatos, Simone Ragusa

The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation. However, the mechanisms of metastatic outgrowth in colorectal cancer remain a major chal ...

Elsevier2014

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Laurent Mouchiroud, Giuseppe Lo Sasso, Alessandra Piersigilli

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

The Bcl9-beta-catenin interface as a potential therapeutic target for colorectal cancer

Andreas Eduard Moor

Aberrantly active Wnt signaling is the hallmark driver of colorectal cancer (CRC). Bcl9/9l proteins are components of the main transcriptional activation complex of canonical Wnt signaling and interact with beta-catenin via a highly conserved homology doma ...

EPFL2014

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

Douglas Hanahan, Anguraj Sadanandam, Krisztian Homicsko, Stephan Wullschleger

Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 ...

Nature Publishing Group2013

Characterization of Three Amino-Functionalized Surfaces and Evaluation of Antibody Immobilization for the Multiplex Detection of Tumor Markers Involved in Colorectal Cancer

Nicolas Xanthopoulos, Vincent Laporte

Antibody microarrays are powerful and high-throughput tools for screening and identifying tumor markers from small sample volumes of only a few microliters. Optimization of surface chemistry and spotting conditions are crucial parameters to enhance antibod ...

Amer Chemical Soc2013

Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells

Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammat ...

2012