Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade

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CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Paolo De Los Rios, Bruno Lemaitre, Evelyne Ruchti, Sylvia Ho, Anthony Vocat, Marine Van Campenhoudt, Samuel Rommelaere, Greta Limoni, Stefano Zamuner, Giovanni D'Angelo, Laura Capolupo, Charlotte Julie Caroline Gehin, Samuel Sagar Kumar, Huixin Guo

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are ...

American Society for Clinical Investigation2023

Fine-tuning the cytotoxicity of ruthenium(ii) arene compounds to enhance selectivity against breast cancers

Paul Joseph Dyson

Ruthenium-based complexes have been suggested as promising anticancer drugs exhibiting reduced general toxicity compared to platinum-based drugs. In particular, Ru(& eta;(6)-arene)(PTA)Cl-2 (PTA = 1,3,5-triaza-7-phosphaadamantane), or RAPTA, complexes have ...

ROYAL SOC CHEMISTRY2023

Wavescapes: A visual hierarchical analysis of tonality using the discrete Fourier transform

Cédric Viaccoz, Martin Alois Rohrmeier, Daniel Harasim, Fabian Claude Moss

Many structural aspects of music, such as tonality, can be expressed using hierarchical representations. In music analysis, so-called keyscapes can be used to map a key estimate (e.g., C major, F minor) to each subsection of a piece of music, thus providin ...

SAGE PUBLICATIONS LTD2022

Improved high-order ambiguity function method for the estimation of phase from interferometric fringes

Pramod Rastogi, Sai Siva Gorthi

Optical Society of America2009