Publication

Halogenated analogs of the antimalarial bialamicol

Manfred Schlosser
1996
Journal Articles

Abstract

In a successful attempt to amplify the pharmacol. activity of the antimalarial bialamicol, substituents were introduced in the 2-position of the allyl side chains. 2-Fluoroallyl bromide, a versatile C3F building block, is described for the first time. While introduction of halogens did not alter the pharmacol. activity, addn. of HBr to the vinyl groups or substitution with Me induce a 500 and 100-fold increase of activity against Leishmania and Trypanosoma, resp. [on SciFinder (R)]

Official source

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Manfred Schlosser
1996
Journal Articles

Abstract

Official source

Related concepts (3)

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Eugenol

Eugenol ˈjuːdʒᵻnɒl is an allyl chain-substituted guaiacol, a member of the allylbenzene class of chemical compounds. It is a colorless to pale yellow, aromatic oily liquid extracted from certain essential oils especially from clove, nutmeg, cinnamon, basil and bay leaf. It is present in concentrations of 80–90% in clove bud oil and at 82–88% in clove leaf oil. Eugenol has a pleasant, spicy, clove-like scent. The name is derived from Eugenia caryophyllata, the former Linnean nomenclature term for cloves.