Publications related to Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression

Related publications (10)

Identification of glutathione transferase (GST P1) inhibitors via a high-throughput screening assay and implications as alternative treatment options for breast cancers

Paul Joseph Dyson, Gerardo Turcatti, Marc Chambon, Jonathan Patrice Vesin

Glutathione S-transferase P1-1 (GST P1) is an important drug target as it is implicated in drug resistance. GST P1-1 inhibitors are typically non-productive analogues of glutathione which covers broad chemical space; hence it is likely that several clinica ...

Public Library of Science (PLoS)2025

Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity

Andrea Cavalli

The RAD51-BRCA2 interaction is central to DNA repair through homologous recombination. Emerging evidence indicates RAD51 overexpression and its correlation with chemoresistance in various cancers, suggesting RAD51-BRCA2 inhibition as a compelling avenue fo ...

SPRINGERNATURE2025

Computational approaches for spatialomics data: construction, integration and analysis of biomolecular atlases

Halima Hannah Emilie Schede

Cellular function and behavior are governed not only by molecular composition but also by a cell's native environmental context. By leveraging in-depth molecular quantification and high-resolution imaging methods to study microenvironmental composition and ...

EPFL2025

Decoding host-microbe interactions with engineered human organoids

Alexandre Louis André Persat, Lucas Andrade Meirelles

As the antimicrobial resistance crisis becomes a reality, we are only now realizing we lack a fundamental understanding of the mechanisms by which major pathogens infect their human host. To address this, we must employ novel methodologies that allow us to ...

SPRINGERNATURE2025

CoNIC Challenge: Pushing the frontiers of nuclear detection, segmentation, classification and counting

Martin Weigert

Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a communitywide challenge using the largest availab ...

Elsevier2023

Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Pierre Vogel, Florence Pojer, Somi Reddy Majjigapu, Aline Emma Christine Reynaud

The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer cells results in t ...

TAYLOR & FRANCIS LTD2022

DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis

Andrea Ablasser

DNA methylation is a fundamental epigenetic modification, important across biological processes. The maintenance methyltransferase DNMT1 is essential for lineage differentiation during development, but its functions in tissue homeostasis are incompletely u ...

WILEY2021

Prognosis of cancer survivors: estimation based on differential equations

Mats Julius Stensrud, Pal Christie Ryalen

We present a method for estimating several prognosis parameters for cancer survivors. The method utilizes the fact that these parameters solve differential equations driven by cumulative hazards. By expressing the parameters as solutions to differential eq ...

2021

A third Notch in colorectal cancer progression and metastasis

Freddy Radtke, Ute Koch

In this issue of JEM, Varga et al. (https://doi.org/10.1084/jem.20191515) describe a mouse model of invasive and metastatic colorectal cancer (CRC) closely resembling the human consensus molecular subtype (CMS) 4 associated with the poorest overall surviva ...

ROCKEFELLER UNIV PRESS2020

Commentary on paper by Leroy C. Stevens (1960)

Denis Duboule

ACADEMIC PRESS INC ELSEVIER SCIENCE2019