Publications related to Extracellular vesicles transfer chromatin-like structures that induce non-mutational dysfunction of p53 in bone marrow stem cells

Related publications (9)

Orchestration of pluripotent stem cell genome reactivation during mitotic exit

David Michael Suter, Cédric Deluz, Ludovica Vanzan, Silja Michelle Placzek

Cell identity maintenance faces many challenges during mitosis, as most DNA-binding proteins are evicted from DNA and transcription is virtually abolished. How cells maintain their identity through division and faithfully re-initiate gene expression during ...

2025

Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure

Johan Auwerx

Chimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show ...

Springer Science and Business Media LLC2025

Multi-motif scaffolding for de novo pathogen antigen mimetics by deep generative learning

Karla Montserrat Castro Gilabert

Proteins are macromolecular machines central to virtually every fundamental biological function. Three-dimensional protein structures, determined by their amino acid composition, are directly linked to their function. Research into structure-function relat ...

EPFL2024

A flexible framework for the design and optimization of water-excitation RF pulses using B-spline interpolation

Daniel Wenz

PurposeTo implement a flexible framework, named HydrOptiFrame, for the design and optimization of time-efficient water-excitation (WE) RF pulses using B-spline interpolation, and to characterize their lipid suppression performance. MethodsAn evolutionary o ...

WILEY2024

Article Structure and functionality of a multimeric human COQ7:COQ9 complex

Matteo Dal Peraro, Luciano Andres Abriata

Coenzyme Q (CoQ) is a redox-active lipid essential for core metabolic pathways and antioxidant defense. CoQ is synthesized upon the mitochondrial inner membrane by an ill-defined "complex Q" metabolon. Here, we present structure-function analyses of a lipi ...

CELL PRESS2022

Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells

Jörn Pezoldt

Acute graft versus host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT) inflicted by alloreactive T cells primed in secondary lymphoid organs (SLOs) and subsequent damage to aGvHD target tissue ...

2022

RosettaSurf-A surface-centric computational design approach

Pierre Vandergheynst, Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Andreas Loukas, Stéphane Rosset, Andreas Scheck, Michaël Defferrard

Proteins are typically represented by discrete atomic coordinates providing an accessible framework to describe different conformations. However, in some fields proteins are more accurately represented as near-continuous surfaces, as these are imprinted wi ...

PUBLIC LIBRARY SCIENCE2022

Toward Biophysical Mechanisms of Neocortical Computation after 50 Years of Barrel Cortex Research

Graham Knott, Carl Petersen, Felix Schürmann

2021

Patterning of cell-instructive hydrogels by hydrodynamic flow focusing

Matthias Lütolf, Steffen Cosson, Simone Allazetta

Microfluidic gradient systems offer a very precise means to probe the response of cells to graded biomolecular signals in vitro, for example to model how morphogen proteins affect cell fate during developmental processes. However, existing gradient makers ...

Royal Society of Chemistry2013