Publications related to Tracking Hyperpolarized [1-¹³C] Pyruvate and [1-¹³C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain

Related publications (10)

Helmet material design for mitigating traumatic axonal injuries through AI-driven constitutive law enhancement

Dominique Pioletti, Pierre-Etienne Bourban, Naser Nasrollahzadeh Mamaghani, Vincent Marc Varanges, Pezhman Eghbalishamsabadi

Sports helmets provide incomplete protection against brain injuries. Here we aim to improve helmet liner efficiency by employing a novel approach that optimizes their properties. By exploiting a finite element model that simulates head impacts, we develope ...

2025

Computational approaches for spatialomics data: construction, integration and analysis of biomolecular atlases

Halima Hannah Emilie Schede

Cellular function and behavior are governed not only by molecular composition but also by a cell's native environmental context. By leveraging in-depth molecular quantification and high-resolution imaging methods to study microenvironmental composition and ...

EPFL2025

Early intensive rehabilitation reverses locomotor disruption, decrease brain inflammation and induces neuroplasticity following experimental Cerebral Palsy

Grégoire Courtine, Yohan Van de Looij, Quentin Barraud, Laetitia Danielle Philippine Baud

Background: Cerebral Palsy (CP) is a major cause of motor and cognitive disability in children due to injury to the developing brain. Early intensive sensorimotor rehabilitation has been shown to change brain structure and reduce CP symptoms severity. We c ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2024

Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

Cristina Ramona Cudalbu Moldovan, Dunja Simicic, Veronika Rackayová

Chronic liver disease (CLD) is a serious condition where various toxins present in the blood affect the brain leading to type C hepatic encephalopathy (HE). Both adults and children are impacted, while children may display unique vulnerabilities depending ...

SPRINGER/PLENUM PUBLISHERS2023

Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia

Ketson Roberto Maximiano Dos Santos

Background: Changes in dynamic cerebral autoregulation (DCA) may contribute to postpartum maternal cerebrovascular complications after preeclampsia. We hypothesized that DCA is impaired in the first week postpartum after diagnosis of preeclampsia with seve ...

2023

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Ece Yildiz, Antoine Jalil, Yu Sun, Francesca Pontanari, Nadia Bresciani, Adrien Faure Garcia

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023

Submillimeter T-1 atlas for subject-specific abnormality detection at 7T

Jean-Philippe Thiran, Tobias Kober, Bénédicte Marie Maréchal, Tom Hilbert, Ricardo Alberto Corredor Jerez, Gian Franco Piredda, Samuele Caneschi

Purpose: Studies at 3T have shown that T-1 relaxometry enables characterization of brain tissues at the single-subject level by comparing individual physical properties to a normative atlas. In this work, an atlas of normative T-1 values at 7T is introduce ...

WILEY2022

Experimental evaluation of direct thromboaspiration efficacy according to the angle of interaction between the aspiration catheter and the clot

Mohamed Bouri, Philippe Reymond

Background Successful direct thromboaspiration (DTA) is related to several factors such as clot consistency, size, and location. It has also been demonstrated recently that the angle of interaction (AOI) formed by the aspiration catheter and the clot is re ...

2021

pH-Dependent Catalytic Reaction Pathway for Water Splitting at the BiVO4−Water Interface from the Band Alignment

Alfredo Pasquarello, Francesco Ambrosio, Julia Anna Wiktor

We align the band edges of BiVO4 at the interface with liquid water by combining advanced electronic-structure calculations, molecular dynamics simulations, and a computational hydrogen electrode. After accounting for spin–orbit coupling and thermal and nu ...

2018

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

Pierre Magistretti, Thierry Laroche, Igor Allaman, Jiangyan Yang

The glyoxalase system is the most important pathway for the detoxification of methylglyoxal (MG), a highly reactive dicarbonyl compound mainly formed as a by-product of glycolysis. MG is a major precursor of advanced glycation end products (AGEs), which ar ...

2011