Publications related to Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

Related publications (10)

Effects of Tetrahydroindenoindole Supplementation on Metabolism: a Systematic Review with Meta-analysis of Rodent-based Studies

Identifying novel compounds with therapeutic potential is a main area of interest in biomedical research. Tetrahydroindenoindole (THII) has emerged as a compound of interest due to both its antioxidant properties and its action as a pharmacological activat ...

SPRINGER2025

Mitochondrial control of ciliary gene expression and structure in striatal neurons

Maria del Carmen Sandi Perez, Olivia Zanoletti, Dogukan Hazar Ülgen, Alessandro Chioino

Mitochondria play essential metabolic roles and are increasingly understood to interact with other organelles, influencing cellular function and disease. Primary cilia, as sensory and signalling organelles, are crucial for neuronal communication and functi ...

WILEY2025

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

Xavier Fernandez-Real Girona

Background: The gut microbiome and iron status are known to play a role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear. Results: Here, we applied an integrative systems medicine approa ...

2021

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Alfio Quarteroni, Francesco Regazzoni, Luca Dede'

Cardiac in silico numerical simulations are based on mathematical models describing the physical processes involved in the heart function. In this review paper, we critically survey biophysically-detailed mathematical models describing the subcellular mech ...

SPRINGER SINGAPORE PTE LTD2021

A Muscle-Reflex Model of Forelimb and Hindlimb of Felidae Family of Animal with Dynamic Pattern Formation Stimuli

Auke Ijspeert

Human and animal locomotion are controlled by complex neural circuits, which can also serve as inspiration for designing locomotion controllers for dynamic locomotion in legged robots. We develop a locomotion controller model including a central pattern ge ...

IEEE2020

Characterization of Coenzyme Q Biosynthesis Proteins through Integrative Modeling at the Protein-Membrane Interface

Deniz Aydin

Integral and peripheral membrane proteins account for one-third of the human proteome, and they are estimated to represent the target for over 50% of modern medicinal drugs. Despite their central role in medicine, the complex, heterogeneous and dynamic nat ...

EPFL2019

In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Carole Poitry-Yamate, Marta Lai

Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution mu ...

2018

Integrated Bio/Nano/CMOS Interfaces for Electrochemical Molecular Sensing

Sandro Carrara

Integrated bio/nano/Complementary Metal-Oxide-Semiconductor (CMOS) interfaces for electrochemical molecular sensing are becoming more and more common in the literature, especially for developing new electronic biochips for smart and intelligent Internet-of ...

WILEY2018

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Johan Auwerx, Matthias Lütolf, Kristina Schoonjans, Dongryeol Ryu, Hongbo Zhang, Davide D'Amico, Keir Joe Menzies, Xu Wang, Karim Laurent Gariani, Peiling Luan

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

American Association for the Advancement of Science2016

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity

Patrick Aebischer, Nicole Déglon, Diana Zala

Transcriptional dysregulation caused by expanded polyglutamines (polyGlns) in huntingtin (htt) may be central to cell-autonomous mechanisms for neuronal cell death in Huntington's disease (HD) pathogenesis. We hypothesized that these mechanisms may involve ...

2006