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Influence of process pressure on local facesheet instability for ultralight sandwich structures

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Effect of water on sandstone's fracture toughness and frictional parameters: Brittle strength constraints

Marie Estelle Solange Violay, Corentin Jean-Marie Rémi Noël

Water presence causes a dramatic reduction of sandstone strength. Under compressive stress conditions, the strength of a rock sample is controlled by frictional parameters and the fracture toughness of the material. Here, we report fracture toughness, fric ...

2021

Electrochemical determination of nicotine in smokers' sweat

Eda Mehmeti, Sandro Carrara, Tugba Kilic

In this work, we report the demonstration of the capability of electrochemical sensors to provide measurements directly on the sweat of volunteers to successfully discriminate heavy smokers by light ones. Since its importance as pharmaceutical treatment-ag ...

ELSEVIER2020

Skin cell analysis

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Milica Jovic, Tzu-En Lin, Yingdi Zhu

The present invention describes an adhesive tape stripping transfer method for quick and non-invasive diagnosis of skin diseases by MALDI-TOF mass spectrometry analysis. Cells from the epidermis layer of a suspicious skin area of a patient are collected us ...

2020

Microfluidics by Additive Manufacturing for Wearable Biosensors: A Review

Christian Enz, Sandro Carrara

Wearable devices are nowadays at the edge-front in both academic research as well as in industry, and several wearable devices have been already introduced in the market. One of the most recent advancements in wearable technologies for biosensing is in the ...

2020

Repetitive regime of highly focused liquid microjets for needle-free injection

Christophe Moser, Paul Delrot, Jan Krizek

Fast liquid jets are investigated for use as a needle-free drug delivery system into an elastic tissue such as skin. Using smaller jet diameters in a repetitive regime can mitigate bruising and pain associated with current injectors. In this study, we aim ...

Nature Research2020

Sweat monitoring with CMOS compatible technology: ISFETS and beyond

Francesco Bellando

In recent years, sweat has gained increasing attention from the scientific community as a new analyte for health monitoring. The main advantage with respect to the "Gold Standard" for laboratory analysis, i.e. blood, is of course the possibility of perform ...

EPFL2020

Mechanical properties and cytocompatibility of dense and porous Zn produced by laser powder bed fusion for biodegradable implant applications

Andreas Mortensen, Ludger Weber

In this work, the macrotexture of dense Zn produced by laser powder bed fusion (LPBF) was studied and the mechanical properties for different tensile bar orientations were measured. The compressive strength of LPBF Zn scaffolds with five different unit cel ...

ELSEVIER SCI LTD2020

Experimental studies of hydro-mechanical couplings in Enhanced Geothermal Reservoirs

Mateo Alejandro Acosta

Enhanced Geothermal Systems (EGS) allow for worldwide geothermal electricity production. They target deep (3-5 km), fractured rock reservoirs whose permeability is artificially increased through hydraulic stimulations (fluid injections). The injections mod ...

EPFL2020

Development of Tissue Kallikrein Inhibitors for the Treatment of Netherton Syndrome

Patrick Andreas Gonschorek

There is currently no approved treatment for Netherton syndrome, which is a severe, genetic skin disease characterized by chronic inflammation and excessive peeling of the skin. Even though the molecular disease mechanism has been assigned to the unopposed ...

EPFL2019

Petrophysical properties of heavy oil-bearing carbonate rocks and their implications on petroleum system evolution: Insights from the Majella Massif

Carolina Giorgetti

In this work, we investigate the role of hydrocarbons in changing the petrophysical properties of rocks by merging laboratory measurements, outcrops characterization, and subsurface data focusing on a carbonate-bearing reservoir (Bolognano Formation) of th ...

2020

Wearable System for Real-Time Sensing of Biomarkers in Human Sweat

Junrui Zhang

Wearable sweat sensing systems offer non-invasive and real-time bio-data streaming solutions. They open the possibility for continuous monitoring of biomarkers' concentrations as well as their variation in sweat, which is a complementary to current passive ...

EPFL2019

Tape-Stripping Electrochemical Detection of Melanoma

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Tzu-En Lin, Yingdi Zhu, Sorour Darvishi

A noninvasive electrochemical melanoma detection approach based on using adhesive tapes for collecting and fixing cells from a suspicious skin area and transferring the cells into a scanning electrochemical microscope (SECM) is presented. The adhesive laye ...

AMER CHEMICAL SOC2019

Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence

Christèle Gonneau, Yann Barrandon, Ariane Rochat, Paola Bonfanti, Stéphanie Claudinot

The formation of hair follicles, a landmark of mammals, requires complex mesenchymal-epithelial interactions and it is commonly believed that embryonic epidermal cells are the only cells that can respond to hair follicle morphogenetic signals in vivo. Here ...

Nature Research2020