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Publication

Skin cell analysis

Hubert Girault, Andreas Stephan Lesch, Horst Pick, Milica Jovic, Tzu-En Lin, Yingdi Zhu
2020
Patents

Abstract

The present invention describes an adhesive tape stripping transfer method for quick and non-invasive diagnosis of skin diseases by MALDI-TOF mass spectrometry analysis. Cells from the epidermis layer of a suspicious skin area of a patient are collected using adhesive tapes via at least one application of tape stripping procedure. The adhesive tapes carrying collected skin cells are analyzed directly with MALDI-TOF MS without any sample pretreatment like cell lysis or preparatory cellular component extraction. Detection and diagnosis of human and mouse melanoma are illustrated as examples in the present invention.

Official source

https://infoscience.epfl.ch/entities/publication/cfb79330-79e8-4e6a-88ce-97a3d37bf82d

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Hubert Girault, Andreas Stephan Lesch, Horst Pick, Milica Jovic, Tzu-En Lin, Yingdi Zhu
2020
Patents

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/cfb79330-79e8-4e6a-88ce-97a3d37bf82d

About this result

Related concepts (20)

Human skin

The human skin is the outer covering of the body and is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue guarding muscles, bones, ligaments and internal organs. Human skin is similar to most of the other mammals' skin, and it is very similar to pig skin. Though nearly all human skin is covered with hair follicles, it can appear hairless. There are two general types of skin, hairy and glabrous skin (hairless). The adjective cutaneous literally means "of the skin" (from Latin cutis, skin).

Time-of-flight mass spectrometry

Time-of-flight mass spectrometry (TOFMS) is a method of mass spectrometry in which an ion's mass-to-charge ratio is determined by a time of flight measurement. Ions are accelerated by an electric field of known strength. This acceleration results in an ion having the same kinetic energy as any other ion that has the same charge. The velocity of the ion depends on the mass-to-charge ratio (heavier ions of the same charge reach lower speeds, although ions with higher charge will also increase in velocity).

Matrix-assisted laser desorption/ionization

In mass spectrometry, matrix-assisted laser desorption/ionization (MALDI) is an ionization technique that uses a laser energy-absorbing matrix to create ions from large molecules with minimal fragmentation. It has been applied to the analysis of biomolecules (biopolymers such as DNA, proteins, peptides and carbohydrates) and various organic molecules (such as polymers, dendrimers and other macromolecules), which tend to be fragile and fragment when ionized by more conventional ionization methods.

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