Gait Assessment in Duchenne Muscular Dystrophy Children during Long-Distance Walking

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progress ...

The natural compound Cyclo Histidine-Proline (CHP) was initially discovered in the brain, but thereafter evaluated in the context of diabetes because of its hypoglycemic action. The pharmacokinetics and the toxicological profile of CHP showed it can be dos ...

The balancing of mechanisms consists in distributing their moving masses, inertias, and elastic components in order to achieve key mechanical properties, such as the elimination of the shaking forces and moments exported onto their supporting structure or ...

Locomotion is based on a sophisticated interaction among the environment, the musculoskeletal system, the spinal cord, and the brain locomotor areas. Quality of life is strongly related to the proper capability of this movement. However, many pathologies, ...

Accurate predictions of how vortices grow, evolve, and separate from aerodynamic objects are desirable for various applications ranging from autonomous aerial vehicles to wind turbines. Here, we present an experimental characterisation of the formation pro ...

The growing demand for online gait phase (GP) estimation, driven by advancements in exoskeletons and prostheses, has prompted numerous approaches in the literature. Some approaches explicitly use time, while others rely on state variables to estimate the G ...

Although theories of emotion associate negative emotional symptoms with cognitive biases in information processing, they rarely specify the details. Here, we characterize cognitive biases in information processing of pleasant and unpleasant information, an ...

Accurate assessment of Parkinson’s disease (PD) ON and OFF states in the usual environment is essential for tailoring optimal treatments. Wearables facilitate measurements of gait in novel and unsupervised environments; however, differences between unsuper ...

Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...

Mobility impairments are a common symptom of age-related degenerative diseases. Gait features can discriminate those with mobility disorders from healthy individuals, yet phenotyping specific pathologies remains challenging. This study aims to identify if ...

Objective To investigate the utility of an automatic deep learning (DL) method for segmentation of T2 maps in patients with idiopathic inflammatory myopathy (IIM) against healthy controls, and also the association of quantitative T2 values in patients with ...

Background: Measuring mobility in daily life entails dealing with confounding factors arising from multiple sources, including pathological characteristics, patient specific walking strategies, environment/context, and purpose of the task. The primary aim ...

Gait assessments in standardized settings, as part of the clinical follow-up of children with cerebral palsy (CP), may not represent gait in daily life. This study aimed at comparing gait characteristics in laboratory and real life settings on the basis of ...

We propose a new control approach for the twisted string actuation (TSA) system; a hybrid control scheme consisting of two nested loops, considering the motor angle and the axial force at the clamping point of the actuator as the system outputs. We show th ...

Like 17 million people worldwide, an individual with cerebral palsy (CP) does not have the opportunity to walk harmoniously in society due to long-life impairments in movement and posture. The natural course of CP can be modulated by treatments and therapi ...

Powered exoskeletons are among the emerging technologies claiming to assist functional ambulation. The potential to adapt robotic assistance based on specific motor abilities of incomplete spinal cord injury (iSCI) subjects, is crucial to optimize Human-Ro ...

Expanded CAG/CTG repeats underlie 13 neurological disorders, including myotonic dystrophy type 1 (DM1) and Huntington's disease (HD). Upon expansion, disease loci acquire heterochromatic characteristics, which may provoke changes to chromatin conformation ...

Macrophages (MPs) are immune cells which are crucial for tissue repair. In skeletal muscle regeneration, pro-inflammatory cells first infiltrate to promote myogenic cell proliferation, then they switch into an anti-inflammatory phenotype to sustain myogeni ...

Mobility concerns most daily tasks (e.g., householding, shopping), affecting life quality. Gait speed, recognized as the sixth vital sign, is a key to characterize mobility. It is also a primary outcome of many clinical interventions. Monitoring gait in un ...

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mecha ...

Gait Assessment in Duchenne Muscular Dystrophy Children during Long-Distance Walking

Chat with Graph Search

Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models

Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy

Mechanism balancing taxonomy

Investigating the neuromechanical control of healthy gait modulation and pathological gaits observed in cerebral palsy using neuromuscular simulations

Strength and timing of primary and secondary vortices generated by a rotating plate

State-Based Versus Time-Based Estimation of the Gait Phase for Hip Exoskeletons in Steady and Transient Walking

Information Processing Biases: The Effects of Negative Emotional Symptoms on Sampling Pleasant and Unpleasant Information

Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease

Metabolic rescue of muscle and muscle stem cells in muscle disease

Gait Variability to Phenotype Common Orthopedic Gait Impairments Using Wearable Sensors

Assessment of idiopathic inflammatory myopathy using a deep learning method for muscle T2 mapping segmentation

Design and validation of a multi-task, multi-context protocol for real-world gait simulation

Comparison of gait characteristics between clinical and daily life settings in children with cerebral palsy

A hybrid control strategy for force and precise end effector positioning of a twisted string actuator

Gait analysis in children with cerebral palsy: bridging the gap between the laboratory and real life

Neuromuscular Controller Embedded in a Powered Ankle Exoskeleton: Effects on Gait, Clinical Features and Subjective Perspective of Incomplete Spinal Cord Injured Subjects

Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion

The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration

Gait in real world: validated algorithms for gait periods and speed estimation using a single wearable sensor

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy