Publication

Development of thermoresponsive liposomes as a delivery system of HRP

2016
Student Projects

Abstract

Significant research in tissue engineering has been devoted to the replication of cartilage by developing suitable scaffolds. The approach of Ren et al was to develop an injectable Hyaluronic acid-tyramine hydrogel. HA-tyr hydrogels can be crosslinked by adding hydrogen-peroxide (H2O2) and the enzyme horse-radish peroxidase (HRP). However, the reaction is almost instantaneous and temporal control is difficult. By separating HRP from HA-Tyr and H2O2, the mixture is liquid. Hence, the main goal of this project was to develop a thermoresponsive system for HRP delivery aiming to trigger and control HA-Tyr crosslinking reaction.

Official source

https://infoscience.epfl.ch/entities/publication/9928a17e-0f6e-4ec7-976d-1d615563ed88

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2016
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/9928a17e-0f6e-4ec7-976d-1d615563ed88

About this result

Related concepts (15)

Tissue engineering

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds.

Chemical reaction

A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and breaking of chemical bonds between atoms, with no change to the nuclei (no change to the elements present), and can often be described by a chemical equation. Nuclear chemistry is a sub-discipline of chemistry that involves the chemical reactions of unstable and radioactive elements where both electronic and nuclear changes can occur.

Hyaluronic acid

Hyaluronic acid (ˌhaɪ.əljʊəˈrɒnɪk; abbreviated HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans as it is non-sulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large: human synovial HA averages about 7 million Da per molecule, or about 20,000 disaccharide monomers, while other sources mention 3–4 million Da.

Related publications (4)

Development of thermoresponsive liposomes as a delivery system of HRP

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