Publication

Photoprotective effect of catechin during ALA-PDT

Georges Wagnières, Jaroslava Joniová
2019
Conference Papers

Abstract

The production of reactive oxygen species (ROS) in normal tissues is associated with side effects of many cancer treatments. This is, in particular, the case for the skin photosensitization experienced by certain patients subjected to PDT based on a systemic administration of photosensitizers (PS). Similarly, the ROS generated in normal tissues during radiotherapies are responsible for the damages induced in various organs, including the skin.

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https://infoscience.epfl.ch/entities/publication/9519f7a6-d52a-4ad2-bab4-2bded5d2feff

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Georges Wagnières, Jaroslava Joniová
2019
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/9519f7a6-d52a-4ad2-bab4-2bded5d2feff

About this result

Related concepts (23)

Photodynamic therapy

Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance, used in conjunction with molecular oxygen to elicit cell death (phototoxicity). PDT is popularly used in treating acne. It is used clinically to treat a wide range of medical conditions, including wet age-related macular degeneration, psoriasis, atherosclerosis and has shown some efficacy in anti-viral treatments, including herpes. It also treats malignant cancers including head and neck, lung, bladder and particular skin.

Photosensitizer

Photosensitizers are light absorbers that alters the course of a photochemical reaction. They usually are catalysts. They can function by many mechanisms, sometimes they donate an electron to the substrate, sometimes they abstract a hydrogen atom from the substrate. At the end of this process, the photosensitizer returns to its ground state, where it remains chemically intact, poised to absorb more light. One branch of chemistry which frequently utilizes photosensitizers is polymer chemistry, using photosensitizers in reactions such as photopolymerization, photocrosslinking, and photodegradation.

Treatment of cancer

Cancer can be treated by surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy (including immunotherapy such as monoclonal antibody therapy) and synthetic lethality, most commonly as a series of separate treatments (e.g. chemotherapy before surgery). The choice of therapy depends upon the location and grade of the tumor and the stage of the disease, as well as the general state of the patient (performance status). Cancer genome sequencing helps in determining which cancer the patient exactly has for determining the best therapy for the cancer.

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