Inferring the age and strength of mutations evolving under positive selection

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The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ cells ...

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The Hsp70 cycle is a key element of protein homeostasis, which is essential to avoid protein aggregation and protein-related diseases. Despite many experimental observations of the interaction between Hsp70, its co-chaperone DnaJ and various substrates, li ...

Inferring the age and strength of mutations evolving under positive selection

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Reproductive isolation arises during laboratory adaptation to a novel hot environment

Euclid preparation XXXVII. Galaxy colour selections with Euclid and ground photometry for cluster weak-lensing analyses

At what spatial scale does natural selection operate? Using multiscale frameworks to calibrate the effects of environmental factors across landscape continuums

Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

Virucidal compounds and use thereof

The role of LRRK2 in lung adenocarcinoma

Peptide-based virucidal drugs

Inactivation of influenza A virus in expiratory droplets and aerosol particles and the associated physicochemical drivers

Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive

Impact of population size on early adaptation in rugged fitness landscapes

Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks

Homogeneous Environmental Selection Structures the Bacterial Communities of Benthic Biofilms in Proglacial Floodplain Streams

PSGL-1 is an evolutionarily conserved antiviral restriction factor

Individual and combined benefits of different nonequilibrium proofreading mechanisms

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Optimization of elastic wave propagation in a reconfigurable medium by genetic algorithms with adaptive mutation probability

Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin

Multivalent Virucidal Antivirals: Synthesis, Mechanisms of Action, and Immune-stimulating Effects

Impact of substrate clogging on vertical connectivity

Why do we need so many proteins? A physical insight into the collaboration of Hsp70 and DnaJ