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The concept, objectives and work proposed by the Guardian Angels for Smarter Life FET Flagship Pilot are designed to result in visionary, science driven, goal-oriented, large-scale, multidisciplinary research flagship proposal, nucleated from ICT future and emerging technologies. Guardian Angels are defined as zero-power intelligent autonomous systems-of-systems featuring sensing, computation and communication and being powered by advanced energy harvesters. In this paper we describe the zero-power technological platform as an enabler of such autonomous smart systems, the related scientific and technical challenges, their possible applications and the societal impact. (C) Selection and peer-review under responsibility of FET11 conference organizers and published by Elsevier B.V.