Publication

Plasmonic Nanostructure Biosensors for Continuous Monitoring and Multiplexed Profiling with Ultra-Broad Dynamic Range

2026

Abstract

Accurate and timely molecular diagnostics remain limited by the static nature of conventional assays, insufficient sensitivity for low-abundance targets, and restricted dynamic range for quantifying both low- and high-abundance biomarkers. Existing methods rely on endpoint measurements that obscure temporal dynamics, require analyte-specific dilutions, and are prone to cross-reactivity in multiplexed formats. To overcome these barriers, this thesis establishes a plasmonic biosensing framework that integrates continuous monitoring, nanoparticle-based amplification, and multiplexed ultrabroad dynamic range detection on engineered nanostructures. In the first part, continuous plasmonic biosensing was realized on surface plasmon resonance (SPR) gold chips through reversible bioassay design. Incorporating regeneration protocols enabled over 100 measurement cycles in buffer with 1 min reset time and

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2026

Abstract

Official source

Related concepts (32)

Colloidal gold

Colloidal gold is a sol or colloidal suspension of nanoparticles of gold in a fluid, usually water. The colloid is coloured usually either wine red (for spherical particles less than 100 nm) or blue-purple (for larger spherical particles or nanorods). Due to their optical, electronic, and molecular-recognition properties, gold nanoparticles are the subject of substantial research, with many potential or promised applications in a wide variety of areas, including electron microscopy, electronics, nanotechnology, materials science, and biomedicine.

Surface plasmon polariton

Surface plasmon polaritons (SPPs) are electromagnetic waves that travel along a metal–dielectric or metal–air interface, practically in the infrared or visible-frequency. The term "surface plasmon polariton" explains that the wave involves both charge motion in the metal ("surface plasmon") and electromagnetic waves in the air or dielectric ("polariton"). They are a type of surface wave, guided along the interface in much the same way that light can be guided by an optical fiber.

Surface plasmon resonance

Surface plasmon resonance (SPR) is a phenomenon that occurs where electrons in a thin metal sheet become excited by light that is directed to the sheet with a particular angle of incidence, and then travel parallel to the sheet. Assuming a constant light source wavelength and that the metal sheet is thin, the angle of incidence that triggers SPR is related to the refractive index of the material and even a small change in the refractive index will cause SPR to not be observed.

Related publications (32)

Plasmonic Nanostructure Biosensors for Continuous Monitoring and Multiplexed Profiling with Ultra-Broad Dynamic Range

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