Periostin Limits Tumor Response to VEGFA Inhibition

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Somatic hypermutation in cancer has gained momentum with the increased use of tumour mutation burden as a biomarker for immune checkpoint inhibitors. Spontaneous deamination of 5-methylcytosine to thymine at CpG dinucleotides is one of the most ubiquitous ...

Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8 liquids per pa ...

The use of CAR technologies has revolutionized cancer treatment. Their unprecedented efficacy against B cell malignancies has opened the doors for a lot of excitement and research in the field. These synthetic receptors are composed of an antigen recogniti ...

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Cancer immunotherapy has become an attractive strategy among different therapeutic modalities over the past few years and has showed great success in the clinic. However, there are many outstanding challenges hindering the current immunotherapies. In my Ph ...

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Dendritic cells (DCs) regulate immune priming by expressing programmed death ligand 1 (PD-L1) and PD-L2, which interact with the inhibitory receptor PD-1 on activated T cells. PD-1 signaling regulates T cell effector functions and limits autoimmunity. Tumo ...

The present invention relates to methods and compositions which provide a companion diagnostic for cancer therapy. A method for identifying and stratifying a patient or group of patients with cancer as (i) being high or low for FMRP activity, (ii) having a ...

Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...

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In the past decades, breakthroughs in cancer immunotherapy have led to unprecedented clinical responses in patients with advanced-stage cancers that would otherwise be fatal. However, treatment of many solid organ malignancies with highly immunosuppressive ...

Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FM ...

Periostin Limits Tumor Response to VEGFA Inhibition

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Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Mechanism of KRAS-driven T cell infiltration in colorectal cancer

Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping

Hyperthermic intrathoracic chemotherapy to control malignant pleural mesothelioma

Il-10 expressing cells for enhanced cancer immunotherapies

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

Balancing the Nanoscale Organization in Multivalent Materials for Functional Inhibition of the Programmed Death-1 Immune Checkpoint

A pan-cancer classification based on fmrp pathway activity that informs differential prognosis and therapeutic responses

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

Metal-organic framework-based hydrogel with structurally dynamic properties as a stimuli-responsive localized drug delivery system for cancer therapy

The role of eosinophils in breast cancer

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

Engineering T Cell Trafficking and Function for Enhanced Cancer Immunotherapy

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion