Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity

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Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnorma ...

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Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity

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