Publication

Les étapes du développement du pancreas: des pistes pour le traitement du diabète [Different steps in pancreas development: toward diabetic therapies?]

2002
Journal Articles

Abstract

The formation of the pancreas from the endoderm layer takes place in different steps including the specification of the precursor territory, the outgrowth of pancreas buds, the differentiation of exocrine and endocrine cells, and the migration of endocrine cells which leads to islet formation. These processes are controlled by mesoderm-endoderm interactions and specific induction of a set of transcription factors. Deciphering the cascade of genes involved in beta-cell induction will provide essential tools to engineer cells for diabetes therapy.

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2002
Journal Articles

Abstract

Official source

Related concepts (32)

Pancreas

The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine gland, i.e., it has both an endocrine and a digestive exocrine function. 99% of the pancreas is exocrine and 1% is endocrine. As an endocrine gland, it functions mostly to regulate blood sugar levels, secreting the hormones insulin, glucagon, somatostatin and pancreatic polypeptide.

Pancreas transplantation

A pancreas transplant is an organ transplant that involves implanting a healthy pancreas (one that can produce insulin) into a person who usually has diabetes. Because the pancreas is a vital organ, performing functions necessary in the digestion process, the recipient's native pancreas is left in place, and the donated pancreas is attached in a different location. In the event of rejection of the new pancreas, which would quickly cause life-threatening diabetes, there would be a significant chance the recipient would not survive very well for long without the native pancreas, however dysfunctional, still in place.

Diabetes

Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body becoming unresponsive to the hormone's effects. Classic symptoms include thirst, polyuria, weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, including disorders of the cardiovascular system, eye, kidney, and nerves.

Related publications (3)

Les étapes du développement du pancreas: des pistes pour le traitement du diabète [Different steps in pancreas development: toward diabetic therapies?]

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MULTIPLE DEFECTS IN MOUSE STEM CELL BASED EMBRYO MODELS LACKING ALL HOX FUNCTION

Discovery of a DNA-based Optical Nanotube Sensor for Glucose Using Clustering and Deep Learning Algorithms

Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids