Publication

Discovery of a DNA-based Optical Nanotube Sensor for Glucose Using Clustering and Deep Learning Algorithms

2025

Abstract

Glucose sensing is vital for managing diabetes. However, current sensors are invasive and secrete enzymatic byproducts that are inflammatory and toxic. Though DNA-wrapped single-walled carbon nanotubes (DNA-SWCNTs) emit fluorescence that is ideal for enzyme-free optical sensing, existing approaches have yet to identify a DNA sequence that can elicit a fluorescence response to glucose. We develop an approach based on clustering to design a diverse library of 90 DNA sequences to screen for a glucose response. The most responsive sequence was further improved based on favorable mutations predicted by deep learning and pattern recognition. This combination of experimental screening and supervised and unsupervised machine learning represents a generalizable approach to developing DNA-SWCNT sensors for even the most elusive analytes.

Official source

https://infoscience.epfl.ch/entities/publication/7daa6f12-b1f4-481f-91f4-f9904274362f

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2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/7daa6f12-b1f4-481f-91f4-f9904274362f

About this result

Related concepts (32)

Deep learning

Deep learning is part of a broader family of machine learning methods, which is based on artificial neural networks with representation learning. The adjective "deep" in deep learning refers to the use of multiple layers in the network. Methods used can be either supervised, semi-supervised or unsupervised.

Blood glucose monitoring

Blood glucose monitoring is the use of a glucose meter for testing the concentration of glucose in the blood (glycemia). Particularly important in diabetes management, a blood glucose test is typically performed by piercing the skin (typically, via fingerstick) to draw blood, then applying the blood to a chemically active disposable 'test-strip'. The other main option is continuous glucose monitoring (CGM). Different manufacturers use different technology, but most systems measure an electrical characteristic and use this to determine the glucose level in the blood.

Glucose meter

A glucose meter, also referred to as a "glucometer", is a medical device for determining the approximate concentration of glucose in the blood. It can also be a strip of glucose paper dipped into a substance and measured to the glucose chart. It is a key element of glucose testing, including home blood glucose monitoring (HBGM) performed by people with diabetes mellitus or hypoglycemia. A small drop of blood, obtained from slightly piercing a fingertip with a lancet, is placed on a disposable test strip that the meter reads and uses to calculate the blood glucose level.

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Discovery of a DNA-based Optical Nanotube Sensor for Glucose Using Clustering and Deep Learning Algorithms

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